Transporters monocarboxylate

Monocarboxylates such as lactic acid and pyruvate are transported across plasma membranes by members of the proton-linked monocarboxylate transporter (MCT)... 

Kim, D. K., et al. Expression cloning of a Na+-independent aromatic amino acid transporter with structural similarity to H+/monocarboxylate transporters. J. Biol. Chern. 2001, 276, 17221-17228. 

Takanaga, H., et al. cDNA cloning and functional characterization of rat intestinal monocarboxylate transporter. Biochem. Biophys. Res. Commun. 1995, 217, 370-377. 

Lieno RL, Gerhart DZ, Duelli R, En-erson BE, Drewes LR. Diet-induced ketosis increases monocarboxylate transporter (MCT1) levels in rat brain. Neuro-chem Int 2001 38 519-527. 

Baud, O., Fayol, L., Gressens, P. etal. Perinatal and early postnatal changes in the expression of monocarboxylate transporters MCT1 and MCT2 in the rat forebrain. /. Comp. Neurol. 465 445-454,2003. 

Pierre, K., Magistretti, P J., Pellerin, L. MCT2 is a major neuronal monocarboxylate transporter in the adult mouse brain. /. Cereb. Blood Flow Metab. 22 586-595, 2002. 

Leino,R.L.,Gerhart,D.Z.andDrewes,L.R.Monocarboxylate transporter (MCT1) abundance in brains of suckling and adult rats a quantitative electron microscopic immunogold study. Brain Res. Dev. Brain Res. 113 47-54,1999. 

Bergersen, L., Rafiki, A. and Ottersen, O. P. Immunogold cytochemistry identifies specialized membrane domains for monocarboxylate transport in the central nervous system. Neurochem. Res. 27 89-96, 2002. 

Rafiki, A., Boulland, J. L., Halestrap, A. P. et al. Highly differential expression of the monocarboxylate transporters MCT2 and MCT4 in the developing rat brain. Neuroscience 122 677-688, 2003. 

Bergersen, L., Waerhaug, O., Helm, J. et al. A novel postsyn-aptic density protein the monocarboxylate transporter MCT2 is co-localized with delta-glutamate receptors in postsynaptic densities of parallel fiber-Purkinje cell synapses. Exp. Brain Res. 136 523-34,2001. 

Broer, S., Broer, A., Schneider, H. P. etal. Characterization of the high-affinity monocarboxylate transporter MCT2 in Xenopus laevis oocytes. Biochem. J. 341 529-535,1999. 

Ritzhaupt A, Wood IS, Ellis A, Hosie KB, Shirazi-Beechey SP (1998) Identification and characterization of a monocarboxylate transporter (MCT1) in pig and human colon Its potential to transport L-lactate as well as butyrate. J Physiol 513 719-732... 

Immunohistochemical study ND not determined GLUT1 facilitative glucose transporter MCT1 monocarboxylate transporter CRT creatine transporter LAT1 L-type amino acid transporter TAUT taurine transporter ENT equilibrative nucleoside transporter Oatp organic anion-transporting polypeptide PAH p-aminohippuric acid RUI retinal uptake index TR-iBRB rat retinal capillary endothelial cells. 

Figure 15.2 Ion transporters in human vaginal-ectocervical epithelial cells, sorted into the apical and basolateral domains of the plasma membrane. Black solid symbols depict electrogenic transporters hatched symbols depict electroneutral transporters. Squares are tight junctions. MCT—monocarboxylate transporter NBC— Na+/HCO co-transporter AE—acid (Cl /HCOj ) exchanger NHE (types 1 or 3)—Na+/H+ exchangers.

Enerson BE and Drewes LR [2003] Molecular features, regulation, and function of monocarboxylate transporters implications for drug delivery. 1 Pharm Sci 92 1531-1544... 

Halestrap AP and Meredith D [2004] The SLC16 gene family-from monocarboxylate transporters (MCTs) to aromatic amino acid transporters and beyond. Pflugers Arch 447 619-628... 

Halestrap AP, Price NT. 1999. The proton-linked monocarboxylate transporter (MCT) family Structure, function and regulation. Biochem J 343 Pt 2 281-299. 

Knott R.M., et al. 1999. A model system for the study of human retinal angiogenesis activation of monocytes and endothelial cells and the association with the expression of the monocarboxylate transporter type 1 (MCT-1). Diabetologia 42 870. 

Philp, N.J., et al. 2003. Polarized expression of monocarboxylate transporters in human retinal pigment epithelium and ARPE-19 cells. Invest Ophthalmol Vis Sci 44 1716. 

Exceptions from Lipinski s rule, i.e., molecules of PSA values > 140 A2 are found to be actively absorbed by carrier-mediated transport systems (Wessel et al. 1998), as shown in Fig. 3. IB. As further detailed in Fig. 3.2, the intestinal epithelium expresses a number of such transport systems for amino acids, organic anions and cations, nucleosides, and hexoses. Among these systems are the apical sodium-dependent bile acid transporter (ASBT Annaba et al. 2007), the monocarboxylate transporter (MCT Halestrap and Price 1999), the sodium-D-glucose co-transporter (SFGT1 Kipp et al. 2003), and the nucleotide transporter SPNT1 (Balimane and Sinko 1999). In addition, the expression of a specialized transporter system for small peptides has been found in the intestinal epithelium with the di/tripeptide transporter, PepTl (Tsuji 2002), after previous functional studies by Hu et al. (1989), and the cloning of PepTl... 

Brooks, G.A., M.A. Brown, C.E. Butz, J.P. Sicurello, and H. Dubouchaud (1999a). Cardiac and skeletal muscle mitochondria have a monocarboxylate transporter MCT1. J Appl. Physiol. 87 1713-718. 

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