Monkeypox

Signs and Symptoms Clinical symptoms in humans similar to that seen in smallpox although often milder. Symptoms include extreme fatigue, fever, muscular, and back pain, with evolution of discolored spots (maculas) progressing successively to elevated bumps (papules), blisters (vesicles), pus filled pimples (pustules), and finally scabs. In addition, infected persons experience enlarged neck and groin lymph nodes. Vaccination with the smallpox vaccine immunizes against monkeypox. 

Fact Sheet Basic Information About Monkeypox." June 12,2003. 

Interim Case Definition for Animal Cases of Monkeypox." Interim Document, June 19, 2003. 

Monkeypox Infections In Animals Updated Interim Guidance for Veterinarian." Guidelines... 

Yes. Vaccinia vaccine is recommended for laboratory workers who directly handle cultures, animals contaminated or infected with, nonhighly attenuated vaccinia virus, recombinant vaccinia viruses derived from nonhighly attenuated vaccinia strains, or other orthopoxviruses that infect humans. These would include monkeypox, cowpox, vaccinia, and variola. Other health-care workers, such as physicians and nurses whose contact with nonhighly attenuated vaccinia viruses is limited to contaminated materials such as medical dressings but who adhere to appropriate infection control measures, are at lower risk for accidental infection than laboratory workers. However, because a theoretical risk for infection exists, vaccination can be offered to this group. Vaccination is not recommended for people who do not directly handle nonhighly attenuated virus cultures or materials or who do not work with animals contaminated or infected with these viruses. 

MONJU fast-breeder reactor, 17 588 Monkeypox, 3 136 Monkshood, 2 103... 

Farnsworth NR, Akerele O, Bingel AS, Soejarto DD, Guo Z. (1985) Can variola-like viruses be derived from monkeypox virus An investigation based on DNA mapping. Bull WHO 63 695-981. 

Smallpox, a DNA virus, is a member of the genus orthopoxvirus, like monkeypox, vaccinia, or cowpox. It contains a large, complex viral genome and is the only... 

Cause for concern is not limited to food products. In 2003, for the first time in the United States, 71 cases of monkeypox were reported from Wisconsin (39), Indiana (16), Illinois (12), Missouri (2), Kansas (1), and Ohio (1) after exposure to pet prairie dogs imported from Ghana. The prairie dogs were infected by a giant Gambian rat from Ghana that was in close proximity during... 

Re-emerging or re-surgtng—infections that existed previously but are increasing in incidence or geographic range, such as the spread of West Nile virus and monkeypox to North America. 

CBCNews (2003). The econoniicimpact of SARS. Retrieved March 27, 2007 from the CBC Web site http //www.cbc.ca/news/ background/sars/economi cimpact.html Centers for Disease Control and Prevention (CDC). (2003a). Questions and answers about monkeypox. Retrieved March 27,2007 from http //www.cdc.gov/ncidod/monkeypox/qa.htm Centers for Disease Control and Prevention. (2003b). Revised U.S. surveillance case definition for severe acute respiratory syndrome (SARS) and update on SARS cases—United States and worldwide, December 2003. Morbidity Mortality Weekly Report, 52(49), 1202-1206. 

Variola, the virus that causes smallpox, is a DNA virus. Like several similar viruses, monkeypox, vaccinia and cowpox, variola is a member of the genus Orthopoxvirus. Although all of these viruses can cause infections and cutaneous... 

Meningococcemia Mercury poisoning Monkeypox Mumps Parvovirus 19 Pertussis Plague Psittacosis Q fever... 

Other experiments which gave rise to concern included work on the synthesis of viruses6 and on the mechanisms by which smallpox interrupts the operation of its host s immune system.7 However, when some thought was given to the discussions provoked by these individual experiments, and their publication, a deeper problem quickly emerged. For example, in regard to the mousepox experiment, it seems that the same experiment was carried out on rabbit-pox and then, by other experimenters, on cowpox (which can jump species). Worse still, there were rumours that it was being contemplated that the experiment should be checked out in monkeypox. 

A. Characteristics. The smallpox virus is an orthopoxvirus with a narrow host range confined to humans. Eradication of the natural disease was completed in 1977. Appearance of human cases would signal use of the virus as a biological weapon. Under natural conditions, the virus is transmitted by direct contact with an infected case, by fomites, and occasionally by aerosols. Smallpox virus is highly stable and retains infectivity for long periods outside of the host. A related virus, monkeypox, clinically resembles smallpox and causes sporadic human disease in West and Central Africa. The incubation period is typically 12 days (range, 10-17 days). 

Cidofovir Treatment of Variola (Smallpox) in the Hemorrhagic Smallpox Primate Model and the IV Monkeypox Primate Model [252]... 

Huggins J W, Zwiers S H, Baker R O, et al. Cidofovir Treatment of Variola (Smallpox) in the Hemorrhagic Smallpox Primate Model and the IV Monkeypox Primate Model. Available http //www.who.int/csr/disease/smallpox/cidofovirtreatment/en/ index.html. 

Karupiah Yes, I think so. In a secondary infection CTLs are not needed, just antibody. In the mousepox model we have done this with a whole range of knockouts as well as depletion of leukocyte subsets. Another group has done this with the monkeypox virus model using monkeys. 

Crimean-Congo hemorrhagic fever virus Variola (smallpox) and monkeypox viruses... 

Using the published sequence of variola and its significant homology with other Orthopoxviruses, a malevolent laboratory could theoretically engineer a recombinant virus exhibiting variola virus s virulence by starting with monkeypox virus. 

Orthopoxvirus Variola, vaccinia, monkeypox, cowpox, rabbitpox, raccoon pox, tatera pox, buffalopox, camelpox... 

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