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Molecular probe chemical structure

These procedures proposed by Dubinin and by Stoeckli arc, as yet, in the pioneer stage. Before they can be regarded as established as a means of evaluating pore size distribution, a wide-ranging study is needed, involving model micropore systems contained in a variety of chemical substances. The relationship between the structural constant B and the actual dimensions of the micropores, together with their distribution, would have to be demonstrated. The micropore volume would need to be evaluated independently from the known structure of the solid, or by the nonane pre-adsorption method, or with the aid of a range of molecular probes. [Pg.227]

FIGURE 5.37 Chemical structure of a molecular probe with UV-Vis and fluorescence outputs for penicillin G amidase activity. The phenylacetamide group (red) is a substrate for PGA. The reporter units, 4-nitrophenol and 6-aminoquinoline, provide a visible signal and a fluorescence signal, respectively, upon release. (See the color version of this figure in Color Plates section.)... [Pg.152]

Alumina is known to have more ionic character and its surface has a more complex structure than that of silica. Reaction of Bu3SnH with the surface of partially dehydroxylated aluminas was followed and it was found that the extreme sensitivity of tin chemical shifts to the molecular environment constitutes a method whereby surface organometallic complexes of tin can be used as molecular probes for determining surface structures of oxides.248... [Pg.270]

NMR is an incredibly versatile tool that can be used for a wide array of applications, including determination of molecular structure, monitoring of molecular dynamics, chemical analysis, and imaging. NMR has found broad application in the food science and food processing areas (Belton et al., 1993, 1995, 1999 Colquhoun and Goodfellow, 1994 Eads, 1999 Gil et al., 1996 Hills, 1998 O Brien, 1992 Schmidt et al., 1996 Webb et al., 1995, 2001). The ability of NMR to quantify food properties and their spatiotemporal variation in a nondestructive, noninvasive manner is especially useful. In turn, these properties can then be related to the safety, stability, and quality of a food (Eads, 1999). Because food materials are transparent to the radio frequency electromagnetic radiation required in an NMR experiment, NMR can be used to probe virtually any type of food sample, from liquids, such as beverages, oils, and broth, to semisolids, such as cheese, mayonnaise, and bread, to solids, such as flour, powdered drink mixes, and potato chips. [Pg.50]

As noted in the Molecular Simulation of Structure and Properties section, there have been no fundamental principle-based mathematical models for Nafion that have predicted new phenomena or caused property improvements in a significant way. This is due to a number of limitations inherent in one or the other of the various schemes. These shortcomings include an inability to sufficiently account for chemical identity, an inability to simulate and predict the long-range structure as would be probed by SAXS or TEM, and the failure to simulate structure over different hierarchy levels. Certainly, advances in this important research front will emerge and be combined with advances in experimentally derived information to yield a much deeper state of understanding of Nafion. [Pg.343]

Abstract Piperazines and its congeners, (di)keto piperazines are valuable tools in drug discovery, providing a natural path for the process peptide > peptidomimetic > small molecule also called depeptisation. Moreover, they can provide molecular probes to understand molecular pathways for diseases of unmet medical need. However, in order to better understand the design of such value added compounds, the detailed understanding of scope and limitation of their synthesis as well as their 3D structures and associated physicochemical properties is indispensables. Isocyanide multicomponent reaction (MCR) chemistry provides a prime tool for entering the chemical space of (di)(keto)piperazines since not less then 20 different ways exist to access a diversity of related scaffolds. [Pg.85]

Pump-probe diffraction techniques offer exciting new ways to probe transient structures in molecular, nanoscale, and biological systems. For dilute systems, or very small targets, electron diffraction is the preferred tool, because the cross sections for scattering of electrons from molecules are very large. In our research we show that pump-probe electron diffraction is an excellent technique to probe the dynamics of chemical reactions in the rarified environment of jet expansions, and for probing the diffraction signatures of individually excited vibronic states. [Pg.19]

Despite its unfavorable NMR properties, the nO nucleus has attracted considerable interest, since its chemical shifts represent a discriminating probe for structural and molecular properties. In a study of some 5-membered heterocycles (furan and isoxazole methyl derivatives) (840MR(22)55) it was found that the nO chemical shifts are mainly determined by the p-electron density on the oxygen atom. A nO downfield shift of 222 ppm is observed on the formal aromatization of tetrahydrofuran to furan (61HCA865). [Pg.67]

BODIPY fluorophores are a relatively new class of probes based on the fused, multiring structure 4,4-difluoro-4-bora-3a,4a-diaza-s-indacene (Fig. 225) (note BODIPY is a registered trademark of Molecular Probes U.S. Patent 4,774,339). This fundamental molecule can be modified, particularly at its 1,3,5,7 and 8 carbon positions, to produce new fluorophores with different characteristics. The modifications cause spectral shifts in its excitation and emission wavelengths and can provide sites for chemical coupling to label other molecules. [Pg.361]

Direct labeling of a biomolecule involves the introduction of a covalently linked fluorophore in the nucleic acid sequence or in the amino acid sequence of a protein or antibody. Fluorescein, rhodamine derivatives, the Alexa, and BODIPY dyes (Molecular Probes [92]) as well as the cyanine dyes (Amersham Biosciences [134]) are widely used labels. These probe families show different absorption and emission wavelengths and span the whole visible spectrum (e.g., Alexa Fluor dyes show UV excitation at 350 nm to far red excitation at 633 nm). Furthermore, for differential expression analysis, probe families with similar chemical structures but different spectroscopic properties are desirable, for example the cyanine dyes Cy3 and Cy5 (excitation at 548 and 646 nm, respectively). The design of fluorescent labels is still an active area of research, and various new dyes have been reported that differ in terms of decay times, wavelength, conjugatibility, and quantum yields before and after conjugation [135]. New ruthenium markers have been reported as well [136]. [Pg.74]

D. Cremer, L. Olsson, and H. Ottosson,/. Mol. Struct. (THEOCHEM), 313, 91 (1994). Calculation of 29Si Chemical Shifts as a Probe for Molecular and Electronic Structure. [Pg.83]

Imaging techniques that utilize low-energy resonant phenomena (electronic, vibrational, or nuclear) to probe the structure and dynamics of molecules, molecular complexes, or higher-order chemical systems differ from approaches... [Pg.69]

Yet the relationship between solute chemical structure and diffusion is not always simple. Werner et al. [248] conducted fluorescence correlation spectroscopic studies of three fluorescent probes in l-butyl-3-methylimidazolium hexafluorophosphate. The probes were chosen to be of comparable molecular structure, but possessed positive, negative, and neutral charges. The authors found that while the neutral probe diffused more rapidly than the cationic probe, the anionic probe diffused the most quickly. [Pg.121]

Although the science of molecular photochemistry remains very active, there is no doubt that in the future photochemists will focus increasingly on supramolecular chemical structures and arrays. This trend is a natural progression as the science of photochemistry meets the demands of new technologies based on advanced materials and as the ability increases to probe complex (photo)biologi-cal processes at the molecular level. [Pg.362]


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See also in sourсe #XX -- [ Pg.152 ]




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Chemical probing

Molecular probe

Molecular probing

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Structure probing

Structured probes

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