Mitogenesis

Ames, B. N., and Gold, L. S. (1990). Too many rodent carcinogens Mitogenesis increases iTiutageiiesis. Science 249, 970-971. 

Ca2+ also plays a role in more prolonged cellular events such as mitogenesis and apoptosis 389... 

Ames BN, Gold LS (1990) Too many rodent carcinogens mitogenesis increases mutagenesis. Science 249 970-971... 

Lavoie, E.T., and Grasman, K.A., Isolation, cryopreservation, and mitogenesis of peripheral blood lymphocytes from chickens (Gallus domesticus) and wild herring gulls (Larus argentatus), Arch. Environ Contam. Toxicol., 48, 552, 2005. 

B-cell Lymphoproliferation Response. The NTP has classified this assay as a Tier I test since mitogenesis can be performed easily in tandem with other tests to provide an assessment of the proliferative capacity of the cells (Luster et al., 1988). Since this assay is performed ex vivo with peripheral blood (or spleen) and is well characterized for use in various animal species, it has also been included as an Expanded Type I test in the revised Redbook. 

Assays such as this that use polyclonal mitogens for activation may not be as sensitive as specific antigen-driven systems (Luster et al., 1988). In addition, suppression of the mitogen response does not always correlate with the PFC response. Since mitogenesis represents only a small aspect of B-cell function and maturation, this endpoint is not sensitive to early events that may affect activation, or later events that may affect differentiation of B cells into antibody-secreting cells (Klaus and Hawrylowicz, 1984). 

Isfort, R.J., Cody, D.B., Doerson, C., Kerckaert, G.A., and LeBoeuf, R.A., Alterations in cellular differentiation, mitogenesis, cytoskeleton and growth characteristics during Syrian hamster embryo cell multistep in vitro transformation, Int. J. Cancer, 59, 114, 1994. 

Auge, N., Nikolova-Karakashian, M., Carpentier, S., Parthasarathy, S., Negre-Salvayre, A., Salvayre, R., Merrill, A.H. Jr, Levade, T, 1999, Role of sphingosine 1-phosphate in the mitogenesis induced by oxidized LDL in smooth muscle cells via activation of sphingomyelinase, ceramidase, and sphingosine kinase, J. Biol. Chem. 274 21533-21538. 

Dumler 1, Stepanova V, Jerke U, Mayboroda OA, Vogel F, Bouvet P, Tkachuk V, Haller H, Gulba DC (1999) Urokinase-induced mitogenesis is mediated by casein kinase 2 and nucleolin. Cutr Biol 9 1468-1476... 

Takata, Y., T. Imamura, M. Iwata, I. Usui, T. Haruta, N. Nandachi, M. Ishiki, T. Sasaoka, and M. Kobayashi. Functional importance of heat shock protein 90 associated with insulin receptor on insulin-stimulated mitogenesis. Biochem Biophys Res Commun. 237 345-7.1997. 

Growth factor- q t/S phase induced mitogenesis Cell survival... 

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