MicroRNA

Kmtzfeldt J, Rajewsky N, Braich R et al (2005) Silencing of microRNAs in vivo with antagomirs . Nature 438 (7068) 685-689... [Pg.1094]

Although we will stick to the IL-6 gene, it should be mentioned at the side that two other RNA polymerases exist in mammalian cells responsible for the synthesis of RNA molecules, which are not translated into proteins ribosomal (rRNA), transfer (tRNA), small nuclear (snRNA), small nucleolar (snoRNA), and some of the recently discovered microRNAs and piRNAs. These RNA molecules act in the process of translation and mRNA turnover. Micro and piRNAs are probably extremely important in the definition of stem cells and of differentiation programs. Some of them are synthesized by RNA polymerase II. [Pg.1225]

Gottwein E, Mukherjee N, Sachse C, Erenzel C, Majoros WH, Chi JT, Braich R, Manoharan M, Soutschek J, Ohler U, Cullen BR (2007) A viral microRNA functions as an orthologue of cellular miR-155.Nature 450 1096-1099... [Pg.22]

Grimson A, Earh KK, Johnston WK, Garrett-Engele P, Lim LP, Bartel DP (2007) MicroRNA targeting specificity in mammals determinants beyond seed pairing. Mol Cell 27 91-105... [Pg.258]

Liu YP, Haasnoot J, Ter Brake O, Berkhout B, Konstantinova P (2008) Inhibition of HIV-1 by multiple siRNAs expressed from a single microRNA polycistron. Nucleic Acids Res 36 2811-... [Pg.260]

Volume 427. MicroRNA Methods Edited fcyJoiiN J. Rossi... [Pg.37]

Methods to Analyze MicroRNA-Mediated Control of mRNA Translation... [Pg.118]

Bhattacharyya, S. N., Habermacher, R., Martine, U., Closs, E. I., and Pilipowicz, W. (2006). Relief of microRNA-mediated translational repression in human cells subjected to stress. Cell 125, 1111-1124. [Pg.144]

Engels, B. M., and Hutvagner, G. (2006). Principles and effects of microRNA-mediated post-transcriptional gene regulation. Oncogene 25, 6163—6169. [Pg.144]

Humphreys, D. T., Westman, B., Martin, D. I., and Preiss, T. (2008). Inhibition of translation initiation by a microRNA. In MicroRNAs From Basic Science to Disease Biology (K. Appasani, ed.), pp. 83—99. Cambridge University Press, Cambridge UK. [Pg.144]

Kim, J., Krichevsky, A., Grad, Y., Hayes, G. D., Kosik, K. S., Church, G. M., and Ruvkun, G. (2004). Identification of many microRNAs that copurify with polyribosomes in mammalian neurons. Proc. Natl. Acad. Sci. USA 101, 360-365. [Pg.145]

Leung, A. K., Calabrese, J. M., and Sharp, P. A. (2006). Quantitative analysis of Argonaute protein reveals microRNA-dependent localization to stress granules. Proc. Natl. Acad. Sci. L7 4 103, 18125-18130. [Pg.145]

Liu, J., Valencia-Sanchez, M. A., Hannon, G. J., and Parker, R. (2005b). MicroRNA-dependent localization of targeted mRNAs to mammalian P-bodies. Nat. Cell Biol. 7, 719-723. [Pg.145]

Maroney, P. A., Yu, Y., Fisher, J., and Nilsen, T. W. (2006). Evidence that microRNAs are associated with translating messenger RNAs in human cells. Nat. Struct. Mol. Biol. 13, 1102-1107. [Pg.145]

Raymond, C. K., Roberts, B. S., Garrett-Engele, P., Lim, L. P., and Johnson, J. M. (2005). Simple, quantitative primer-extension PCR assay for direct monitoring of microRNAs and short-interfering RNAs. RNA 11, 1737-1744. [Pg.146]

Shi, R., and Chiang, V. L. (2005). Facile means for quantifying microRNA expression by real-time PCR. Biotechniques 39, 519-525. [Pg.146]

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