New Horizons Urinary MicroRNAs and Nephrotoxicity in NHPs

The evaluation of urinary microRNAs (miRNAs) as potential biomarkers of nephrotoxicity in NHPs is a recent advancement in discovery toxicology. Human TaqMan  

Low Density Array (TLDA) cards contain miRNA probes which may be used when profiling miRNAs in Cynomolgns monkey, while next-generation sequencing (NGS) appears to be a more comprehensive approach for this purpose. Preliminary results obtained in the context of consortia like the HESl Biomarkers of Nephrotoxicity Committee and the PSTC NWG have shown that urinary miRNAs could potentially be used as sensitive biomarkers of nephrotoxicity in NHPs and support translation across species. 

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