Neurons mammalian

Lonart G, Johnson KM Inhibitory effects of nitric oxide on the uptake of [3H]dopamine and [3H]glutamate by striatal synaptosomes. J Neurochem 63 2108—2117, 1994 Lovinger DM, White G Ethanol potentiation of 5-hydroxytryptamine3 receptor-mediated ion current in neuroblastoma cells and isolated adult mammalian neurons. Mol Pharmacol 40 263—270, 1991... 

Anis, N.A. Berry, S.C. Burton, N.R. and Lodge, D. The dissociative anaesthetics, ketamine and phencyclidine selectively reduce excitation of central mammalian neurones by N-methyl-aspartate. Bj J. Pharmacol 79 565-575, 1983. 

Kim, J., Krichevsky, A., Grad, Y., Hayes, G. D., Kosik, K. S., Church, G. M., and Ruvkun, G. (2004). Identification of many microRNAs that copurify with polyribosomes in mammalian neurons. Proc. Natl. Acad. Sci. USA 101, 360-365. 

Oblinger, M. M., Brady, S. T., McQuarrie, I. G. and Lasek, R. Differences in the protein composition of the axonally transported cytoskeleton in peripheral and central mammalian neurons. /. Neurosci. 7 453-462,1987. 

Mayer, M. L. and Vyklicky, L., Jr. (1989) Concanavalin A selectively reduces desensitization of mammalian neuronal quisqualate receptors. Proc. Natl. Acad. Sci. USA 86, 1411-1415. 

R. Elinas, The intrinsic electrophysiological properties of mammalian neurons a new insight into CNS function, Science 242, 1654-1664 (1988). 

MacDonald, R.L. and Barker, J.L., Anticonvulsant and anesthetic barbiturates different postsynaptic action in cultured mammalian neurons, Neurology, 29, 432-4-11, 1979. 

The situation for Na+ is quite different because both the concentration gradient and At// favor Na+ influx. The intracellular Na+ concentration in a mammalian neuron is about 15 mM, and the extracellular concentration is about 150 mM. Combining the concentration and electrical terms in this case gives... 

A physiological role for the CaMK cascade in activating CREB transcriptional activity in neurons in vivo has been demonstrated in C. elegans. As in mammalian neurons, C. elegans neurons also express a gene homologous to crebl, called crh-1 (Kimura et al., 2002). CRH-1 must be phosphorylated at S129 (the equivalent site... 

Anis NA, Berry SC, Burton NR, Lodge D (1983) The dissociative anaesthetics, ketamine and phencyclidine, selectively reduce exdtation of central mammalian neurones by /V-methyl-aspartate. Br J Pharmacol 79(2) 565-575... 

Ansanay H, Dumuis A, Sebben M, Bockaert J, Fagni L. cAMP-dependent, long-lasting inhibition of a K+ current in mammalian neurons. Proc Natl Acad Sci... 

Condorelli DF, Belluardo N, Trovato-Salinaro A, Mudo G (2000) Expression of Cx36 in mammalian neurons. Brain Res Rev 32 72-85. 

Curtis, D. R., and Watkins, J. C. (1963). Acidic amino acids with strong excitatory actions on mammalian neurones. / Physiol. 166, 1-14. 

I have a question about the diversity of channels, and the degree to which one sees incomplete inactivation in different Na channels. As Richard Keynes has pointed out, this is seen in many channels other than the squid channel. The other striking characteristic about the squid channel is that you get more occupation of the late open state with increasing depolarization. I would ask the group as a whole are there other cases where this increase in late openness is seen as you depolarize beyond about —10 mV Have people looked for this with the cloned channels, to see whether the incomplete opening increases with depolarization It seems to me to be a distinctive property of the squid axon sodium channel. It is not obvious in the cases of mammalian neurons that I have looked at, even though we have looked for this occasionally in hippocampal neurons. 

White G, Lovinger DM, Weight FF 1989 Transient low-threshold Ca current triggers burst firing through an afterdepolarizing potential in an adult mammalian neuron. Proc Natl Acad Sci USA 86 6802-6806... 

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