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MicroRNAs pathway

Ambros, V. 2003. MicroRNA pathways in flies and worms Growth, death, fat, stress, and timing. Cell 113 673-6. [Pg.118]

John, M., Constien, R., Akinc, A., Goldberg, M., Moon, Y., Spranger, M., et al. (2007). Effective RNAi-mediated gene silencing without interruption of the endogenous microRNA pathway. Nature, 449, 745-747. [Pg.50]

Grimm D, Streetz KL, Jopling CL et al (2006) Fatality in mice due to oversaturation of cellular microRNA/short hairpin RNA pathways. Nature 441 537-541... [Pg.70]

Winter J, Jung S, Keller S et al (2009) Many roads to maturity microRNA biogenesis pathways and their regulation. Nat Cell Biol 11 228-234... [Pg.364]

Felicetti F, Errico MC, Bottero L, Segnahni P, Stoppacciaro A, Biffoni M, Felh N, Mania G, Petrini M, Colombo MP, Peschle C, Care A (2(X)8) The promyelocytic leukemia zinc finger-microRNA-221/-222 pathway controls melanoma progression through multiple oncogenic mechanisms. Cancer Res 68 2745-2754... [Pg.817]

Fig. 3 The microRNA (miRNA) pathway. An miRNA is first transcribed as part of an imperfect hairpin in a longer Pol II transcript with 5 cap (open circle) and polyadenosine tail (AAAAAA). The hairpin (pre-miRNA) is removed from the transcript by the nuclear RNase III type enzyme Drosha and its partner, DGCR8. Exportin-5 (Xpo-5) transports the resulting by-product to the cytoplasm, where Dicer liberates a short-lived miRNA duplex. The duplex is unwound, and one strand enters RISC. If the miRNA is mismatched to its target (left), it does not induce cleavage, but may inhibit translation. With a perfect or near-perfect match (right), the target RNA is destroyed by RISC. Fig. 3 The microRNA (miRNA) pathway. An miRNA is first transcribed as part of an imperfect hairpin in a longer Pol II transcript with 5 cap (open circle) and polyadenosine tail (AAAAAA). The hairpin (pre-miRNA) is removed from the transcript by the nuclear RNase III type enzyme Drosha and its partner, DGCR8. Exportin-5 (Xpo-5) transports the resulting by-product to the cytoplasm, where Dicer liberates a short-lived miRNA duplex. The duplex is unwound, and one strand enters RISC. If the miRNA is mismatched to its target (left), it does not induce cleavage, but may inhibit translation. With a perfect or near-perfect match (right), the target RNA is destroyed by RISC.
Kefas B, Godlewski J, Comeau L, Li Y, Abounader R, Hawkinson M, Lee J, Fine H, Chiocca EA, Lawler S, Purow B 2008. microRNA-7 inhibits the epidermal growth factor receptor and the Akt pathway and is down-regulated in glioblastoma. Cancer Res 68(10) 3566-3572. [Pg.471]

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See also in sourсe #XX -- [ Pg.3148 ]



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MicroRNA

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