Microarray technology

Microarray technology has been developed to detect and analyze proteins or nucleic acids within a sample. These devices use highly parallel hybridization assays using an array of testing sites with deposited samples on a chip or slide (88). 

Inkjet printing techniques can be used that forcibly eject fluid droplets from a printhead structure. The ejected droplets fly through the air and land on the substrate. The methods of traditional inkjet printers cannot be directly translated to microarray applications. 

For example, in microarray applications, the droplets contain specific quantities of biological materials. Unfortunately, the number of samples deposited per area on the surface may vary widely because of splashing or spreading of droplets on the printing surface, which could result in inconsistent hybridization data being generated. 

An improved method has been described that uses pins that exhibit a selective wettabihty. For example, silicon pins can be selectively coated with poly(tetrafluoroethylene) hexamethyldisUazane or octadecyl tricholorosUane (88). 

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Bioinformatics Gene Expression Analysis Microarray Technology Pharmacogenetics Proteomics... 

The most common application of microarray technology is in monitoring gene expression (gene expression profiling). 

Microarray Technology Through Applications (2007) Ed. F. Falciani, Taylor and Francis ISBN 9780415378536... 

Microarray Hybridization Microarray Technology Microbial Resistance to Drugs Microfrlaments Microtubule... 

Khan J et al DNA microarray technology the anticipated impact on the study of human disease. Biochim Biophys Acta 1999 1423 M17. 

Lettieri, T., Recent applications of DNA microarray technology to toxicology and ecotoxicology,... 

Al-Khaldi, S. F. Martin, S. A. Rasooly, A. Evans, J. D. DNA microarray technology used for studying foodborne pathogens and microbial habitats Minireview. J. AOAC Int. 2002,85, 906-910. 

Nevertheless, even with these caveats it is likely that mRNA microarray technology will play an increasing role in biological science. The technology... 

Haab BB Advances in protein microarray technology for protein expression and interaction profiling. Curr Opin Drug Discovery Dev 2001 4 116-123. 

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