Proteomic technologies antibody microarrays

However, recombinant antibodies may be less stable and have lower binding affinities than monoclonal antibodies (Valle and Jendoubi, 2003). Therefore, in order to fully implement the microarray format, a host of diverse capture agents could be required in addition to antibodies. These include peptides, small molecules, aptamers, ribozymes, or other molecular recognition probes yet to be discovered. However, it is also xmderstandable because of the diverse nature of proteins that additional technologies besides microarrays will be used in proteomics research (Hanash, 2003). 

Usui-Aoki K, Shimada K, Nagano M, Kawai M, Koga H (2005) A novel approach to protein expression proWfing using antibody microarrays combined with surface plasmon resonance technology. Proteomics 5 2396-2401... 

While the popularity of antibody-antigen microarrays remains on the increase, other approaches are also useful in proteomic studies. Phylos technology (Weng et al., 2002) makes use of mRNA-protein fusion products that... 

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