MHC antigens

MHC antigens and P2-macroglobulin are amongst the best known proteins whose synthesis is also induced in a variety of cell types in response to various interferons. 

Singh, P.B., Brown, R.E. and Roser, B. (1987) MHC antigens in urine as olfactory recognition cues. Nature 327, 161-164. 

Ciubotariu R, Colovai AI, Pennesi G, Liu Z, Smith D, Berlocco P, et al Specific suppression of human CD4+ Th cell responses to pig MHC antigens by CDS + CD28- regulatory T cells. J Immunol 1998 161 5193-5202. 

Hughes, A., Brock, J. H., Parrott, D. M., and Cockbum, F. (1988). The interaction of infant formula with macrophages Effect on phagocytic activity, relationship to expression of class II MHC antigen and survival of orally administered macrophages in the neonatal gut. Immunology 64, 213-218. 

The MHC-antIgen complex activates the T cell receptor and the T cell secretes cytokines. 

APC, antigen-presenting cell and, class I and II major histocompatibility complex (MHC) antigens o and , peptides from degraded antigen bound to MFIC molecules ... 

X, Ig receptor V, class II MHC antigen receptor o, peptide from degraded foreign antigen T cell receptor ... 

Ubiquitin-dependent proteolysis is as important for the regulation of cellular processes as for the elimination of defective proteins. Many proteins required at only one stage of the eukaryotic cell cycle are rapidly degraded by the ubiquitin-dependent pathway after completing their function. The same pathway also processes and presents class I MHC antigens (see Fig. 5-22). Ubiquitin-dependent destruction of cyclinis critical to cell-cycle regulation (see Fig. 12-44). The E2 and E3 components of the ubiquitination cascade pathway... 

At this point, the endosome may fuse with vesicles containing newly synthesized or recycling major histocompatibility complex (MHC) antigens. Some of the partially degraded antigenic fragments may form a complex with the MHC and be transported back to the cell surface. There they are presented to the circulating T-helper (Th)... 

Simpson, A.J., Singer, D., McCutchan, T.F., Sacks, D.L. and Sher, A. (1 983) Evidence that schistosome MHC antigens are not synthesized by the parasite but are acquired from the host as intact glycoproteins. Journal of Immunology 131, 962-965. 

Human cells express a series of proteins on their surface that are involved in self-recognition and in antigen presentation to effector cells for the stimulation of immune reactions. These are called major histocompatibility (MHC) antigens, and each occurs in a variety of allelic forms. People, therefore, differ from each other in their MHC genotypes. As well as affecting transplant compatibility, certain genotypes have been implicated in predisposition to autoimmune disease. 

Hydrophilic surfactant proteins A (SP-A) and D (SP-D), secreted by type II pneumocytes, interact specifically with a wide range of microorganisms and play important roles in the innate, natural defense system of the lung [16]. Both mRNA and protein levels of SP-A and SP-D increase dramatically in response to lung infection, injury and endotoxin challenge [17]. Type II pneumocytes also express class II major histocompatibility complex (MHC) antigens and intracellular adhesion molecule (ICAM-1), which may facilitate pulmonary immune responses [15]. 

Garcia, K. C., Degano, M., Pease, L. R., Huang, M., Peterson, P. A. et al. (1998). Structural basis of plasticity in T cell receptor recognition of a self peptide-MHC antigen. 

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