Antigen Presentation and MHC Restriction

Weller, P.F., Rand, T.H., Barrett, T., Elovic, A., Wong, D.T, and Finberg, R.W. (1993). Accessory cell function of human eosinophils HLA-DR dependent, MHC-restricted antigen-presentation and interleukin-la formation. J. Immunol. 150, 2554-2562. 

Weller PF, Rand TH, Barrett T, Elovic A, Wong DT, Finbeig RW Accessory function of human eosinophils. HLA-DR-dependent, MHC-restricted antigen-presentation and lL-1 alpha expression. J Immunol 1993 150 2554-2562. 

CD lb Known to be present on thymocytes and dendritic cells CDlc Isoform c also known as non-classical MHC class I-like surface antigen present on thymocytes CD2 Defines T cells involved in antigen non-specific cell activation CD3 Also known as T cell receptor-associated surface glycoprotein on T cells CD4 Defines MHC class Il-restricted T cell subsets... 

Meyer, D and Torres, J.V. (1999) Hypervariable epitope construct a synthetic immunogen that overcomes MHC restriction of antigen presentation. Mol. Immunol. 36, 631-637. 

Class I MHC molecules, recognized by killer T-cells are expressed on virtually all nucleated cells. This makes sense, because cytotoxic, killer Tcells must be able to identify all cells that can become infected. Class II MHC molecules are more restricted and are confined to antigen-presenting cells (APCs). i... 

Cohen CJ, Sarig O, Yamano Y, Tomaru U, Jacobson S, Reiter Y (2003) Direct phenotypic analysis of human MHC class I antigen presentation Visualization, quantitation, and in situ detection of human viral epitopes using peptide-specific, MHC-restricted human recombinant antibodies. J Immunol 170 4349 361. 

Rock, K.L., Rothstein, L., Fleishacker, C. and Gamble, S. (1992). Inhibition of class I and class II MHC-restricted antigen presentation by cytotoxic T lymphocytes specific for an exogenous antigen. J. Immunol. 148, 3028-3033. 

B lymphocytes (B cells). Bone marrow-derived lymphocytes, expressing an antigen-receptor complex composed of membrane-bound - immunoglobulin (mlg) and associated molecular chains. B cell receptors interact with epitopes directly (no MHC restriction). Activated B lymphocytes produce antibody and are efficient antigen-presenting cells. They are the precursors of plasma cells. 

A classic paper by Zinkernagel and Doherty in 1974 (Zl) showed that in order for T cells to recognize a foreign antigen, the antigen has to be presented by cells displaying the MHC antigens of the host. The phenomenon became known as MHC restriction. ... 

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