Methyl w-amyl ketone

In a 3-I. round-bottom flask, fitted with an efficient Liebig condenser (100 X 1 cm.), 228 g. (2 moles) of methyl w-amyl ketone (Org. Syn. 7, 60) is dissolved in a mixture of 600 cc. of 95 per cent alcohol and 200 cc. of water. One hundred and thirty grams (5.4 moles) of sodium in the form of wire is gradually added through the condenser. During the addition of the sodium the flask is cooled with running water (Note 1) so that the reaction does not become unduly violent (Note 2). 

Heptanol-2 has been prepared by the action of w-amyl magnesium bromide on acetaldehyde,1 and by the reduction of methyl w-amyl ketone in alcoholic solution by means of sodium.2... 

With methyl w-amyl ketone this process was repeated three times after the first separation. In the case of higher ketones a fewer number of separations is required, while with the simpler ketones a greater number is advisable, on account of their solubility in water. 

With the lower molecular weight ketones it is advantageous to distil the calcium chloride solution to recover the dissolved ketone. This is carried out exactly as described for the separation from the water. With methyl w-amyl ketone the loss is slight if a sufficiently concentrated solution of calcium chloride is employed. 

METHYL AMYL KETONE or METHYL w-AMYL KETONE (110-43-0) Forms explosive mixture with air (flash point 102°F/38°C). Violent reaction with strong oxidizers, aldehydes, nitric acid, perchloric acid. A variety of unstable peroxides may be formed from the reaction with hydrogen peroxide. Incompatible with aliphatic amines, aldehydes, strong bases, hydrogen peroxide, nitric acid, perchloric acid. Attacks some plastics and rubber. 

Johnson BL et al Neurobehavioral effects of methyl w-amyl butyl ketone and methyl -amyl ketone in rats and monkeys Summary of NIOSH investigations.7 wz iro Pathol Toxicol 2 113-133, 1979... 

Methyl ra-amyl ketone has been prepared by the hydration of heptine-x and of heptine-2 under various conditions,1 and by heating n-amyl propiolic acid with potassium hydroxide.2 It has also been obtained by the oxidation of methyl w-amyl carbinol with chromic acid.3... 

Chem. Descrip. High m.w. acrylic polymer in solv. blend (heptane/methyl n-amyl ketone/VM P naphtha, 45/38/15/2 pbw)... 

Butylacetone. See Methyl n-amyl ketone 4-t-Butylacetophenone 4 -t-Butylacetophenone. See p-t-Butyl acetophenone p-t-Butyl acetophenone CAS 943-27-1 EINECS/ELINCS 213-399-3 Synonyms Acetophenone, 4 -t-butyl- 4-t-Butylacetophenone 4 -t-Butylacetophenone Ethanone, 1-[4-(1,1-dimethylethyl) phenyl]-Empirical C12H16O Properties M.w. 176.26 Uses Fragrance in cosmetics Manuf./Distrib. ABCR http //www.abcr.de, Acros Org. http //www.acros.be] Advanced Synthesis Tech, http //www.advancedsynthesis.com] Alfa Aesar http //www.aifa.com] Fluorochem USA http //WWW. fiuorochemusa. com Butyl acetoxystearate Empirical C24H46O4... 

See, Ethyl w-amyl Ketone, Methyl w-hexyl Ketone, and Propyl w-butyl Ketone. 

Ammonium sulfide, 3, n Ammonium thiocyanate, 7, 48 Ammonolysis, 4, 3 7, 16 o-Amyl alcohol, 1, 4, 10 Amyl alcohol, active, 7, 77 mo-Amyl Bromide, 1,1, 2, 4, 10 w-Amyl Methyl Ketone, 7, do -Amyl propiolic acid, 7, 62 Analysis of Benzoylhydroperoxide, 8,32 Analysis of Benzoylperoxide, 8, 31 Anhydro-o-Hydroxymercoribenzoic Acid, 7, 3... 

According to the submitters, methyl amyl ketone (800 g.) and ammonia (600 cc.) have been converted to 2-aminoheptane, b.p. 139-141°, in exactly the same manner, in 50-55 per cent yields. A slightly modified procedure was used in the preparation of w-heptylamine and furfurylamine. Heptaldehyde (320 g.) was dissolved in 500 cc. of methanol, and 150 cc. of liquid ammonia was added the reduction was conducted as above. w-Heptyla-mine, b.p. 57-58°/23 mm., was obtained in yields of 53-63 per cent. Freshly distilled furfural (290 g.) was dissolved in 500 cc. of methanol, 150 cc. of liquid ammonia was introduced, and the reduction carried out as usual. The product was removed, filtered, and fractionated directly. Furfurylamine, b.p. 144-146°, was obtained in 50 per cent yield. 

On the other hand, Gavrilova and Gonikberg opened the furan ring with hydrogen, without the use of catalysts.213 The reaction is carried out at high temperature (350-375°) and at a pressure between 240 and 750 atmospheres, in the absence of a solvent. The following products are obtained from 2-methylfuran acetone, methyl ethyl ketone, methyl butyl ketone, methyl amyl ketone, acetophenone, methylpropylcarbinol, w-pentane, and water. The authors suggest that these products are formed by a free radical mechanism. 

See Methyl ra-deoyl Ketone, Ethyl nonyl Ketone, and w-Amyl n-besyl 2-Bodedne. 

Coatings and sealants for varied industrial applications are made by dissolving compounds of low-viscosity FKM elastomers, such as VITON C-10, VITON A-35, or FLUOREL 2145, in methyl ethyl ketone, ethyl acetate, methyl isobutyl ketone, amyl acetate, or other related ketones.47 Such products have typical useful storage life of 7 days at 24°C (75°F) and cure within 2 weeks.58 The subject of coatings and sealants based on fluoroelastomers is covered in more detail in Modern Fluoropoly-mers (Scheirs, J., Ed.), Chapter 23 (Ross Jr., E. W. and Hoover, G. S.), John Wiley Sons, New York (1997). 

Mr W.D. Field groups the solvents of pyroxyline into classes thus Two of the monohydric alcohols compound ethers of the fatty acids with monohydric alcohols, aldehydes simple and mixed ketones of the fatty acid series. These four classes inelude the greater number of the solvents of pyroxyline. Those not included are as follows —Amyl-nitrate and nitrite, methylene-di-methyl ether, ethidene-diethyl ether, amyl-chloracetate, nitro-benzene and di-nitro-benzene, eoumarin, eamphor, glacial acetic acid, and mono-, di-, and tri-acetin. 

Secondary Butyl Acetate Methyl Isobutyl Ketone Methyl Isobutyl Ketone (82.5% w)— Methyl Isobutyl Carbinol (17.5% w) Normal Butyl Acetate Mesityl Oxide Secondary Amyl Acetate Amyl Acetate (mixed isomers)... 

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