Phosphonic acid, methyl

B) The preparation of (cis-1,2-epoxypropyi)phosphonic acid [ (1 -chloroethoxy )chloro-methyl] phosphonic acid (1.0 g) is added with stirring to tetrahydrofuran (50 ml) to which has been added a crystal of iodine and a zinc-copper couple (15.0 g). The mixture is then heated under reflux for 24 hr and the resulting solution filtered to yield (cis-1,2-epoxy propyl )-phosphonic acid. 

Plugging solution contains Portland cement, sodium sulphate, potassium ferricyanide and nitrile-tri-methyl-phosphonic acid. Patent SU 1700204-A, 1991. 

P. F. Tsytsymushkin, S. R. Khajmllin, A. P. Tamavskij, Z. N. Kudryashova, and B. V. Mikhajlov. Plugging solution contains Portland cement, sodium sulphate, potassium ferricyanide and nitrile-tri-methyl-phosphonic acid. Patent SU 1700204-A, 1991. 

Once inside the body, diisopropyl methylphosphonate is rapidly converted to isopropyl methyl-phosphonic acid (IMPA), which is rapidly cleared from the blood. Laboratory tests can determine the amount of IMP A in the blood or urine. However, because IMPA leaves the body rapidly, these tests are useful only for recent exposure. It is helpful for your doctor to know whether there are other chemicals to which you have been exposed. See Chapters 2 and 6 for more information. 

The perylene chromophotes were modified by covalently attaching different side groups. Two bulky groups (tertiary-butyl), indicated by a prime, prevented dimerization of neighbouring perylene chromophores when attached to the surface. Linkage to the semiconductor was achieved by different anchor-cum-spacer groups carbonic acid (-COOH) [4], propionic acid (-CH2-CH2-COOH) [2], phosphonic acid (-P(0)(OH)2) [4], methyl-phosphonic acid (-CH2-PO(OH)2) [2] and a -Tripod (see inset in Fig.2) [5], The preparation and sensitization of the nano-structured TiC>2 film and further experimental details have been described before [2]. 

Fig. 3 Separation of standard and liver phospholipids by HPLC on a 5-yttm Nucleosil 5 NH2 stationary phase with an isocratic mobile phase consisting of acetonitrile, methanol, water, and methyl phosphonic acid and subsequent UV and fluorescence detection. The second column was cut off from the eluent stream by valve switching after about 30 min. (Reprinted from Ref. 43 with the kind permission of Analytical Biochemistry.)...

The best known of these defoliants are sodium chlorate which has the danger of starting fires, tributyl-phosphorotrithioite (merphos, Folex) its oxygenated relative tributylphosphorotri-thioite (DEF), and endothall (Accelerate). Recent research reports claim that amino methyl phosphonic acid and certain of its relatives were found to be more active than current commercial products. The best known desiccant used for defoliation of cotton is paraquat (1,1 -dimethyl-4,4 -bipyridinium) (8). 

Figure 2. The effect of derivatization on methylphosphonic acid (a) methyl phosphonic acid analyzed as solid KBr pellet, (b) dimethyl methylphosphonate analyzed with cryodeposition-FTIR, and (c) bis(trimethylsilyl) methylphospho-nate (CAS 18279-83-9) analyzed with cryodeposition-FTIR (Source M. Soderstrom, unpublished results)...

Chloro methyl ethyl sulfide phorate 2 Chloro methyl phenol ethiofencarb Chloro methyl phosphonic acid glyphosate... 

C8H24O12N2P4S, thiobis(ethylene nitrilo)tetra(methyl phosphonic acid) ... 

Sarin and its corresponding nontoxic hydrolysis products (IMPA, and additional methyl phosphonic acids) are predominantly eliminated via the kidneys which are thus more important for detoxification than the liver (Little et al, 1986 Waser and Streichenberg, 1988). Urinary excretion happens quite rapidly as demonstrated for single dose s.c. application of sarin, cyclosarin, and soman to rats (Shih et al, 1994). The terminal elimination half-life was found to be 3.7 =E 0.1 h for sarin and 9.9 0.8 h for cyclosarin. In contrast soman showed a biphasic elimination with terminal half-fives of about 18.5 h and 3.6 h (Shih et al, 1994). Maximum peak levels of sarin metabolites in urine were detected 10-18 h after exposure (Minami et al, 1997) and after 2 days hydrolyzed sarin metabolites had been excreted nearly quantitatively (Shih et al, 1994). In contrast, even at 5 days post-exposure soman metabolite recovery was only 62% (Shih et al, 1994). Excretion of soman from blood, fiver, and kidney compartments following cfiemical and enzymatic hydrolysis is considered a first-order elimination process (Sweeney et al, 2006). 

FIGURE 52.1. Metabolic detoxification of warfare nerve agents tabun, sarin, soman, and VX in mammals in vivo. Chemical names of metabolites are EDMPA - ethyl dimethylaminophosphoric acid, IMPA - isopropyl methylphosphonic acid, PMPA - pinacolyl methyl-phosphonic acid, EMPA - ethyl methylphosphonic acid, and MPA - methylphosphonic acid. 

N,N -BIS(1,1-DIMETHYLETHYL)-1,2-ETHANEDIAMINE see DEClOO 3-((3,5-BIS(l,l-DIMETHYLETHYL)-4-HYDROXYPHENYL)METHYLENE)-l-METHOXY-2-PYRROUDINONE see MELIOO ((3,5-BIS(l,l-DLMETHYLETHYL)-4-HYDROXYPHENYL)METHYL)PHOSPHONIC ACID, MONOETHYL ESTER, NICKEL(2+) SALT (2 1) see BJK560... 

Out own research indicates, however, that the reaction product from CH2 0 and P4 consists actually of equal amounts ( 30% each) of hydroxyme-thyl-phosphonic acid (75), bis (hydroxymethyl)phosphinic acid (74), and me-thyl-hydroxymethyl-phosphinic acid (75). Small amounts of methyl-phosphonic acid and tris (hydroxymethyl)phosphine oxide were also detected... 

S. Farquharson, A. Gift, P. Maksymiuk, F. Inscore and W. Smith, pFI dependence of methyl phosphonic acid, dipicohnic acid, and cyanide by surface-enhanced Raman spectroscopy, Proc. SPIE 5269,117 (2004). 

Baija. B.C., Tejedor-Tejedor. M.L, and Anderson, M.A., Complexation of methyl-phosphonic acid with the surface of goethite particles in aqueous solution, Langmuir, 15,2316. 1999. 

Methyl Phosphonic Acid, Dimethyl Ester A223 Precursor 128... 

Hydrolysis Methyl phosphonic acid (MPA) (993-13-5) High low volatility resistant to photolysis resistant to hydrolysis high water solubility mobile in soils resistant to biodegradation RfD 20 pg/kg/day RfC 24 pg/m3... 

GD (soman pinacolyl Hydrolysis Methyl phosphonic acid (MPA) High RfD 20 -ig/kg/day... 

US EPA (2005b). Isopropyl methyl phosphonic acid. IRIS online database http //www.epa.gov/ iriswebp/iris/index.html. Washington, DC US Environmental Protection Agency, retrieved April 18, 2005. 

Williams RT, Miller WR III and MacGillivray AR (1987). Environmental Fate and Effects of Tributyl Phosphate and Methyl Phosphonic Acid. CRDEC-CR-87103 NTIS AD-A184 959/5. Aberdeen Proving Ground, MD US Army Armament Munitions Chemical Command, Chemical Research, Development and Engineering Center West Chester, PA Roy F Weston. 

The [dichloro(trimethylsilyl)methyl]phosphonic acid derivatives (166 R =MeO or Et2N) are readilyavailable from the corresponding derivative of (trichloromethyl)phosphonic acid, chlorotrimethylsilane, and hexamethylphosphorous triamide. They are versatile intermediates from which the silyl group can be removed during alkylation or acylation so yielding (a,a-dichloroalkyl)- or (a,a-dichloro-2-oxoalkyl)phosphonic... 

Bellstein Handbook Reference) AI3-08678 BRN 0878263 CCRIS 876 DImethoxymethyl-phosphIne oxide Dimethyl methanephosphonate Di-methyl methylphosphonate DMMP EINECS 212-062-3 Fyrol DMMP HSDB 2590 Methyl phosphonic acid, dimethyl ester NCI-C54762 NSC 62240 Phosphonic add, methyl-, dimethyl ester Pyrol dmmp. Flame retardant for applications where high phosphorus content, good solvency, and low viscosity are desired lowers viscosity of epoxy resins and unsaturated polyesters filled with hydrated alumina oxide. Liquid bp = 181 , bp20 = 79.6" d ° = 1.4099 Am = 217 nm (e = 13, EtOH) soluble in H2O, Et20, EtOH LDsO (rat orl) > 5000 mg/kg. Akzo Chemie. 

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