Ethyl methylphosphonic acid

Reactivity Hydrolysis products Ethyl methylphosphonic acid, 2-(Diethylamino) ethanethiol, and P,P-diethyl dimethyldiphosphonate... 

Fig. 11 Effect of the proportion of methanol in the 5 mL MeCN washing fractions on extraction recovery of ethyl methylphosphonic acid (EMPA) on the MIP and the NIP, respectively (The polymers have been named B to differentiate them from another preparation A in the same paper) [49]...

Soil Diesel in CH2C12 O-Ethyl methylphosphonic acid 2.B.4... 

M. Katagi, M. Nishikawa, M. Tatsuno and H. Tsuchihashi, Determination of the main hydrolysis product of O -ethyl, Y-2-di isopropyl amino-ethyl methylphosphonothiolate, ethyl methylphosphonic acid, in human serum, 7. Chromatogr., B, 689, 327-333 (1997). 

FIGURE 52.1. Metabolic detoxification of warfare nerve agents tabun, sarin, soman, and VX in mammals in vivo. Chemical names of metabolites are EDMPA - ethyl dimethylaminophosphoric acid, IMPA - isopropyl methylphosphonic acid, PMPA - pinacolyl methyl-phosphonic acid, EMPA - ethyl methylphosphonic acid, and MPA - methylphosphonic acid. 

Ethyl methylphosphonic acid (EMPA) Ethyl hydrogen methylphosphonate C3H9O3P 1832-53-7 Hydrolysis of VX... 

Diisopropylaminoethyl) O -ethyl methylphosphonate 2-(bis( 1 -Methylethyl)amino)ethyl methylphosphonic acid C H26N03P 71840-26-1 Present in tonne containers... 

Nerve agent residues remaining in the natural environment are likely to undergo substantial hydrolysis in the period immediately following dissemination. In investigation of allegations of use it is therefore important to analyse for trace levels of hydrolysis products. The important hydrolysis products of sarin, soman and GF are the isopropyl, pinacolyl and cyclohexyl methylphosphonic acids, which are slowly hydrolysed further to methylphosphonic acid. VX is predominantly hydrolysed to ethyl methylphosphonic acid... 

VX may be destroyed by chemical incineration or molten metal reduction (see Section 39.2). Groenewold et al. (2002) studied the hydrolysis of VX on concrete surface. The principal degradation product was identified as diisopropylaminoethanethiol produced from the cleavage of P-S bond. Other degradation products were ethyl methylphosphonic acid aud N, N-diisopropylvinylamine, the latter arising from the cleavage of S-C bond. 

Ethyl methylphosphonic acid Ethyl methylphosphonothioic acid Methylphosphonic acid... 

N -butylphosphonic acid, phenylphosphonic acid, ethyl methylphosphonic acid, ethyl methylthiophosphonic acid, isopropyl methylphosphonic acid, pinacolyl methylphosphonic acid, dimethyl phenylphosphonate in 16 min Methylphosphonic acid, ethylphosphonic acid, CZE... 

Kaaijk and Frijlink (1977) and Verweij and Boter (1976) reported on the degradation (presumably by all processes) of VX in soil under laboratory conditions. Degradation was rapid with formation of ethyl methylphosphonic acid and diisopropyl ethyl mercaptoamine. After 1 d, the applied concentration of 0.2 mg/g soil decreased to 22% in humic sand and 2% in humic loam and clayey peat. Only 0.1% of applied VX was detectable in all soils after 3 wk. The half-life of ethyl methylphosphonic acid was 8 d the degradation product was methyl phosphonic acid. Binding of the metabolites but not the parent compound correlated positively with the amount of organic matter in the soil. Small (1984)... 

Fig. 1 HPLC-ESP MS reconstructed (total) ion chromatogram from a standard mixture of alkyl phosphonic acids at a concentration of 1 p-g/ml each 1) methylphosphonic acid (MPA) 2) ethylphosphonic acid (EPA) 3) methyl ethylphosphonic acid (MEPA) 4) ethyl methylphosphonic acid (EMPA) 5) ra-propylphosphonic acid (nPrPA) 6) ethyl ethylphosphonic acid (EEAP) 7) isopropyl methylphosphonic acid (iPrMPA) 8) n-propyl methylphosphonic acid (nPrMPA) 9) isopropyl ethylphosphonic acid (iPrEPA) 10) n-propyl ethylphosphonic acid (nPrEPA) 11) isohutyl methylphosphonic acid (iBuMPA) 12) cyclohexyl methylphosphonic acid (CHMPA) 13) pinacolyl methylphosphonic acid (PinMPA).

Fig. 2 HPLC ICP-MS single ion monitoring (SIM) from a standard mixture of three alkyl phosphonic acids at a concentration of lOOng/ml each 1) methylphosphonic acid (MPA) 2) ethyl methylphosphonic acid (EMPA) 3) isopropyl methylphosphonic add (iPrMPA).

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