Methyl phosphonic acid diphenyl ester

SYNS DIPHENYL METHANEPHOSPHONATE DIPHENYL METHYLPHOSPHONATE PHOSPHONIC ACID, METHYL-, DIPHENYL ESTER SAFETY PROFILE A poison by ingestion. When heated to decomposition it emits toxic vapors of POx. 

PHOSPHONIC ACID, 1-HYDROXY-l.l-ETHANEDIYL ESTER see HKS780 PHOSPHONIC ACID, (1-HYDROXYETHYLIDENE)BIS- see HKS780 PHOSPHONIC ACID, METHYL-, DIPHENYL ESTER see MDQ825... 

PNOCi2H,2, Phosphinic amide, diphenyl-lanthanoid complexes, 23 180 PNOSiCi2Hi Phosphinimidic acid, P-methyl-P-phenyl-N-(trimethylsilyl)-2,2,2-trifluoroethyI ester, 25 72 PN04CsH,g, Phosphonic acid, [(N,N-di-diethyIcarbamoyl)methylJ-, dimethyl ester, 24 101... 

The reaction of 6-methylpyridine-3-carboxylic acid methyl ester with N,0-dimethylhydroxylamine and isopropyl-magnesium chloride in toluene gives the N-methoxyamide derivative (x), which is reduced with diisobutyl aluminium hydride (DIBAL) to afford 6-methylpyridine-3-carbaldehyde (xi). The reaction of the aldehyde (xi) with a phosphite provides the diphenyl phosphonate derivative, which is condensed with 4-(methylsulfonyl)benzaldehyde in the presence of potassium fe/f-butoxide in HF to yield the enimine (xii). Finally, this compound is hydrolyzed with HCI to yield the ketosulfone (ix). 

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