Phosphonic acid, methyl diethyl

Diethyl ami nomethylphosphonate Phosphonic acid, (aminomethyl)-, diethyl ester (50917-72-1 ), 65, 119 DIETHYL N-BENZYLIDENEAMINOMETHYLPHOSPHONATE PHOSPHONIC ACID, [[(PHENYLM THYLENE)AMINO]METHYL]-, DIETHYL ESTER ... 

DIETHYLPHOSPHONOMETHYL-2,2-DIHETHYL-l, 3-DI0XEN-4-0NE, 66, 194-196, 202 Diethyl phthalimidomethylphosphonate Phosphonic acid, (phthalimidomethyl)-, diethyl ester Phosphonic acid, [(1,3-dihydro-l,3-d1oxo-2H-iso1ndol-2-yl)-methyl]-, diethyl ester (33512-26-4), 65, 119 DIHYDROJASMONE, 65, 26... 

Diethyl [(2-tetrahydropyranyloxy)methyl]phosphonate Phosphonic acid, [[(tetrahydro-2H-pyran-2-yl)oxy]methyl]-, diethyl ester (10) (71885-51-3) Diethyl hydroxymethylphosphonate Phosphonic acid, (hydroxymethyl)-, diethyl ester (8,9) (3084-40-0)... 

In order to synthesize biologically relevant phosphonylimidazole 73, bromoimidazole 72 was derived from radical-initiated bromination of methyl l-p-methoxybenzyl-2-thiomethyl-5-imidazolylcarboxylate (71) [56]. The thiomethyl group served to block the C(2) position, which would otherwise undergo preferential halogenation under these conditions. As expected, a variety of Arbusov-Michaelis reaction conditions failed even under forcing conditions. On the other hand, Pd-catalyzed phosphorylation of 72 with diethyl phosphite led to methyl-4-diethylphosphonyl-l-p-methoxybenzyl-2-thiomethyl-5-imidazolylcarboxylate (73). After further manipulations, the desired phosphonic acid-linked aminoimidazoles, which resembled intermediates formed during purine biosynthesis, were accessed. 

Diethylphosphonomethyl-2,2-dimethyl-1,3-dioxen-4-one Phosphonic acid, [(2,2-dimethyl-4-oxo-4H-l, 3-dioxin-5-yl)methyl] -, diethyl ester (11) (81956-28-7)... 

PHOSPHONIC ACID [[(PHENYLHETHYLENE)AMIN0]METHYL, DIETHYL ESTER, 65, 119... 

Reaction of 4-aryl-7-iodoperhydropyrido]2,l-c][l,4]oxazin-6-ones (07USA2007/0117839, 08WOP2008/013213) and 7-iodo-6-oxo-4-(3,4,5-tri-fluorophenyl)perhydropyrido[2,l-a]pyrazine-2-carboxylate (07USA2007/ 0117839) with P(OEt)3 at 120 °C for 2 h afforded 7-phosphonic acid diethyl esters. 3-Hydroxy-6-arylperhydropyrido[2,l-c][l,4]oxazin-4-ones first were reacted with triphenylphosphonium bromide in refluxing MeCN, then with 3-methoxy-4-(4-methyl-lH-imidazol-l-yl)benzaldehyde at ambient temperature in the presence of NEt3 to provide (Z)-3- l-[3-methoxy-4-(4-methyl-lH-imidazol-l-yl)phenyl]methylidene] derivatives (07USA2007/ 0117798, 08USA2008 /0207900). 

DIETHYL N-BENZYLIDENEAMINOMETHYLPHOSPHONATE PHOSPHONIC ACID, [[(PHENYLMETHYLENE)AMINO]METHYL)-, DIETHYL ESTER ... 

Diethyl N-benzylideneaminomethylphosphonate Phosphonic acid, [[(phenylmethylene)amino]methyl]-, diethyl ester (9) (50917-73-2) 2-Methyl-2-phenyl-4-pentenal 4-Pentenal, 2-methyl-2-phenyl- (8,9) (24401-39-6)... 

NO4PC10H22, Phosphonic acid, [(N,N-didi-ethylcarbamoyl)methyl-], diethyl ester, 24 101... 

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