1.1.1- Trifluorides amines methyl groups

Aberle and collaborators started from a Boc-protected benzylic tyrosine derivative. The amino group was methylated (in a yield of 96%) and the corresponding amide formed (86%) after treatment with diethylaminosulfur trifluoride and an amine. 

Lesma and associates began their synthesis of (-b)-monomorine I (1562) with the N-Boc -protected amine 1623, a simple derivative of (5)-pyroglu-tamic acid (Scheme 205). Reaction with allyltrimethylsilane in the presence of boron trifluoride according to a reported procedure and replacement of the Boc group by Cbz produced the 2,5-n s-disubstituted pyrrolidine (—)-1624, cross-metathesis of which with methyl vinyl ketone... 

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