Pyrimidine, 5-methyl-, amination

The first pyrimidine analogues of sulfanilamide were introduced in 1942, some five years after the start of the bacterial chemotherapy revolution. Sulfadiazine (1018 R = R = H) and sulfamerazine (1018 R = Me, R = H) may be made by treatment of pyrimidin-2-amine or its 4-methyl derivative, either with p-acetamidobenzenesulfonyl chloride followed by... [Pg.150]

Oxazolo[4,5-6]pyridin-2(3 H)-one IR, 6, 653 <76HCA1593) Oxazolo[4,5-fi]pyridin-2(3H)-one, 3-(4-chlorophenyl)-3a,7a-dihydro-6-methyl-X-ray, 6, 647 <79CPB2261) Oxazolo[4,5-6]pyridin-2(3H)-one, 3-(4-chlorophenyl)-3a,7a-dihydro-7a-methyl-X-ray, 6, 647 <79CPB2261) 5H-Oxazolo[3,2-a]pyridin-3(2H)-one, 2-phenyl-6,7,8,8a-tetrahydro-X-ray, 6, 646 <77MI42902) Oxazolo[5,4-d]pyrimidin-4-amine, A7-methyl- H NMR, 6, 650 <70BCJ3909)... [Pg.39]

Pyrimidin-2-amine, 4-ethyI-5-(2 -hydroxy-4 -nitrophenyI)-6-methyl-synthesis, 3, 121 Pyrimidin-2-amine, 4-methyl-basic pXj, 3, 61 Pyrimidin-2-amine, N-methyl-hydrolysis, 3, 84 synthesis, 3, 135 Pyrimidin-2-amine, 5-nitro-basic pXj, 3, 61 hydrolysis, 3, 84 Pyrimidin-2-amine, 4-phenyl-synthesis, 3, 109 Pyrimidin-2-amine, 5-phenyl-nitration, 3, 78... [Pg.802]

Pyrimidin-4-amine, 2,6-dichloro-SchiS base, 3, 85 thioalcoholysis, 3, 101 Pyrimidin-4-amine, 2,6-diethyl-5-methyl-synthesis, 3, 116... [Pg.802]

Pyrimidin-4-amine, N, N-dimethyl-2-methylthio-demethylation, 3, 95 Pyrimidin-4-amine, 5-ethoxy methyl-... [Pg.802]

Pyrimidin-5-amine, 2,4-dioxy-6-ribitylamino-in riboflavin biosynthesis, 1, 93 Pyrimidin-5-amine, 2-methyI-in thiamin biosynthesis, 1, 99 Pyrimidin-5-amine, 4-methyl-synthesis, 3, 130... [Pg.802]

Nielsen (81CS(18)135) prepared thieno[2,3-4]pyrimidin-4(3//)-ones in 43-90% yield by heating 2-acylaminothiophene-3-carboxylates (330) with phosphorus pentoxide, N,N -dimethylcyclohexylamine and an amine hydrochloride at 180 °C. By raising the temperature to 240 °C, thieno[2,3-4]pyrimidin-4-amines (331) were obtained in 27-34% yield (Scheme 92). Phenyl N,N -dimethylphosphorodiamidate [(MeNH)2P(0)OPh], a well-known reagent for the synthesis of 3-methyl-4-oxo-3,4-dihydroquinazolines (77S180), reacts with thiophene derivatives of type (330) to give 3-methylthieno[2,3-4]pyrimidin-4(3/f)-ones (78ACS(B)303). [Pg.1017]

Pyrimidin-4-amine, 5-isopropenyI-synthesis, 3, 122 Pyrimidin-4-amine, 5-isopropyl-synthesis, 3, 122 Pyrimidin-4-amine, 2-methyl-synthesis, 3, 120... [Pg.802]

DIETHYL-0-(p-(METHYLSULFINYL)PHENYL) PHOSPHOROTHIOATE see FAQ800 0,0-DIETHYL-0-p-(METHYLSULFINYL)PHENYL THIOPHOSPHATE see FAQ800 N,N-DIETHYL-5-METHYL-(l,2,4)TRIAZOLO(l,5-a)PYRIMIDINE-7-AMINE see DI0200 DIETHYL-NICODYMIDE see DJS200... [Pg.1628]

Big Chemical Encyclopedia

Chemical substances, components, reactions, process design ...