Methyl biphenyl amine

P entanitroanilino toluenes, C H NeO10, mw 408.24, N 20.59% were not found in Beil or CA through 1956. There is, however, PentQr nitro-N-methyUp-bipkenylamine, known also as N-Uetkyl-N,2,21,41,6-penttmitroxenyl-amine,which has the same empirical formula as above. This expl compd is described in this work under Methyl biphenyl amine and Derivatives... 

Bei der uber Dehydrobenzol verlaufenden Reaktion von Fluorbenzol mit N,N-Dimethyl-anilin und Bu-tyllithium in Hexan erhalt man in niedriger Ausbeute ein Gemisch von Methyl-diphenyl-amin (Hauptpro-dukt) und 2-Dimcthylamino-biphenyl... 

Limit values for primary aromatic amines, aromatic aminosulfonic acids, certain cancerogenic amines (e.g., benzidine, 2-naphthylamine, 4-aminobiphenyl and 2-methyl-4-chloroaniline) and for polychlorinated biphenyls (PCB) should be viewed in the listed references of the specific country. 

The synthesis of valsartan (2) by Novartis/Ciba-Geigy chemists is highlighted in Scheme 9.5. Biphenylbenzyl bromide 18 is converted to biphenyl acetate 19 in the presence of sodium acetate in acetic acid. Hydrolysis of 19 followed by Swern oxidation delivered the biphenyl aldehyde 20, which underwent reductive amination with (L)-valine methyl ester (21) to give biphenyl amino acid 22. Acylation of 22 with penta-noyl chloride (23) afforded biphenyl nitrile 24, which is reacted with tributyltin azide to form the tetrazole followed by ester hydrolysis and acidihcation to provide valsartan (2). [See Biihlmayer et al. (1994, 1995).]... 

Others 1,4-dioxane, 1,3,5-trioxane, terahydrofuran, 2-butyl tetrahydrofuran, N,N-dimethylformamide, N,N-dimethylacetamide, epsilon-caprolactam, benzothiazole, biphenyl, pyrazine, 2-butanone oxime, l-methyl-2-pyrrolidone, N,N-dimethyl-aniline, N,N-dimethyl-p-toluidine, l-methyl-7-isopropyl phenanthrene, dibenzyl-amine, hexamethylenetetramine, squalene, 2-ethylanthraquinone... 

S)-N-(l-Carboxy-2-methyl-prop-l-yl)-N-pentanoyl-N-[2 -(lH-tetrazol-5-yl)biphenyl-4-ylmethyl]-amine. The product can be prepared starting from 1.40 g of N-valeryl-N-[(2 -cyanobiphenyl-4-yl)methyl]-(L)-valine methyl ester and 2.25 g of tributyltin azide with subsequent flash chromatography melting interval 105°-115°C (from ethyl acetate). 

Di-tert,-butylphosphino)-biphenyl has been used by Buchwald [5] et al. as the most efficient ligand in the Pd-catalyzed amination of aryl chlorides. 2-Chloro-4-methyl-toluene can be aminated with pyrrolidine in 98% yield using sodium-tert.-butoxide [eq. (e)]. 

Deoxytazettine neomethide (31), a key degradation product of tazettine, has been prepared (Scheme 4).11 The biphenyl derivative (28), obtained in low yield by Ullman condensation, was converted into the cyano-oxepin (29) in two steps (34% overall yield). Reduction gave the amine (30), which upon resolution followed by reductive methylation provided a sample of (—)-deoxytazettine neomethide (31) that was identical (including optical rotation) with the degradation product of tazettine. 

CE has been used for the analysis of chiral pollutants, e.g., pesticides, polynuclear aromatic hydrocarbons, amines, carbonyl compounds, surfactants, dyes, and other toxic compounds. Moreover, CE has also been utilized to separate the structural isomers of various toxic pollutants such as phenols, polyaromatic hydrocarbons, and so on. Sarac, Chankvetadze, and Blaschke " resolved the enantiomers of 2-hydrazino-2-methyl-3-(3,4-dihydroxyphenyl)propanoic acid using CD as the BGE additive. The CDs used were native, neutral, and ionic in nature with phosphate buffer as BGE. Welseloh, Wolf, and Konig investigated the CE method for the separation of biphenyls, using a phosphate buffer as BGE with CD as the chiral additive. Miura et al., used CE for the chiral resolution of seven phenoxy acid herbicides using methylated CDs as the BGE additives. Furthermore, the same group resolved 2-(4-chlorophenoxy) propionic acid (MCPP), 2-(2,4-dichlorophenoxy) propionic acid (DCPP), (2,4-dichlorophenoxy) acetic acid (2,4-D), 2-(4-chlorophenoxy) propionic acid (2,4-CPPA), [(2,4,5-... 

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