Metastasis cell trafficking

VI. Influence of the Immune Surveillance System on Metastasis Cell Trafficking 360... 

Although the utility of PET imaging to study cell trafficking in this chapter has focused on tumor metastasis as an illustration of the relevant principles involved, similar approaches might be useable with other cell types, especially those with elevated glucose metabolism. Hematopoietic cells or some precursor (stem) cells are also possible candidates. 

Kucia M, Reca R, Miekus K, et al. Trafficking of normal stem cells and metastasis of cancer stem cells involve similar mechanisms pivotal role of the SDF-1-CXCR4 axis. Stem Cells 2005 23 879-894. 

Similar to sialic acid, L-fucose is usually displayed as a terminal sugar in glycans allowing it to readily participate in cell-cell interactions and modulate cell motility and migration processes connected with fertilization, embryogenesis, lymphocyte trafficking, immune responses, and cancer metastasis [134,135,136]. To date, many of the specific roles of fucose have been traced... 

Other members of the Ig-superfamily function in conjunction with counter-receptors from separate families of adhesion molecules in various events such as leukocyte trafficking and the movement of immune cells and probably tumor cells across cell barriers in inflammation and metastasis. These glycoproteins (Fig. 10) are the immune cell adhesion molecules ICAM-1, -2 and -3, the vascular cell adhesion molecule VCAM and the platelet-endothelial cell adhesion molecule PECAM [131-134]. 

The chemokines were originally described as specific mediators of leukocyte directional movement. In the cnrrent view, however, they are implicated in the movement of several cell types, and participate in functions snch as lymphocyte trafficking (1), regulation of T cell differentiation (2), HIV-1 infection (3), angiogenesis (4), development (5, 6), and tnmor metastasis (7). 

We then examined the trafficking of B16BL6 cells in the presence of these inhibitors. As shown in Fig. 14.4(a), accumulation of [2- F]FDG-labeled B16BL6 cells in the lungs was suppressed in the presence of sLe -liposome, but was not affected by the liposome modified with methylated sLe (Me-sLe ), which lacked the ability to bind to selectins. Neither the Me-sLe -hposome nor the nonmodified liposome suppressed B16BL6 metastasis to the lungs. Interestingly, the RGD-related peptide did not reduce the accumulation... 

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