Cells metastasis

Kawada K, Sonoshita M, Sakashita H, et al. Pivotal role of CXCR3 in melanoma cell metastasis to lymph nodes. Cancer Res 2004 64 4010 1017. 

The physiological function of heparin is not completely understood. It is found only in trace amounts in normal circulating blood. It exerts an antihpemic effect by releasing lipoprotein lipase from endothehal cells heparinlike proteoglycans produced by endothelial cells have anticoagulant activity. Heparin decreases platelet and inflammatory cell adhesiveness to endothelial cells, reduces the release of platelet-derived growth factor, inhibits tumor cell metastasis, and exerts an antiproliferative effect on several types of smooth muscle. 

Considering the many interactions of heparinoids with the various proteins and the multitude of resulting biologicd activities, including effects on tumour cell metastasis, angiogenesis, asthma, and immune cell migration in inflammation, it is clear that heparinoids and especially heparinoid mimetics may be useful not only in anticoagulation but also in a series of other indications [31]. 

Veinberg G, Vorona M, Shestakova I, Kanepe I, Lukevics E (2003) Some of the more notable advances concern the development of mechanism-based serine protease inhibitors of elastase, cytomegalovirus protease, thrombin, prostate specific antigen, and cell metastasis and as inhibitors of acyl-CoA cholesterol acyl transferase. Curr Med Chem 10 1741... 

Protein-carbohydrate interactions are important in cellular signaling and cancer cell metastasis [16, 17]. The ability to monitor the interactions in a quantitative. 

Honn, K. V., Busse, W. D. and Sloane, B. F. (1983). Prostacyclins and thromboxanes implications for their role in tumor cell metastasis. Biochem. Pharmacol. 32,1-11. 

Ramshaw, I. A., Carlsen, S., Wang, H. C. and Badenoch-Jones, P. (1983). The use of cell fusion to analyse factors involved in tumour cell metastasis. Int. J. Cancer 32, 471 78. 

Vlodavsky, I., Fuks, Z. and Schirrmacher, V. (1983). In vitro studies on tumor cell interaction with the vascular endothelium and the subendothelial basal lamina relationship to tumor cell metastasis. In The Endothelial Cell-a Pluripotent Control Cell of the Vessel Wall (Thilo-Koemer, D. G. S. and Freshney, R. 1., eds.). Karger, Basel, pp. 126-157. 

Carbohydrates specifically mediate numerous biological processes that include cell adhesion and differentiation, pathogen invasion, tumor cell metastasis, and inflammatory responses and are therefore of great interest for the generation of therapeutics (/-i). Unfortunately, the molecular basis for most of... 

Fig. 2 Stimulation of colon cancer cell metastasis to LNs by expression of CXCR3. (A) Partial structures are shown for the construct (top), and empty vector pMX-IRES-EGFP used as the...

Honn KV. Inhibition of tumor cell metastasis by modulation of the vascular prostacyclin/ thromboxane A2 system. Clin Exp Metastasis. 1 (1983) 103-114. 

Honn KV, Tang DG, Gross IM, Renaud C, Duniec ZM, Johnson CR, Diglio CA. Enhanced endothelial cell retraction mediated by 12(S)-HETE a proposed mechanism for the role of platelets in tumor cell metastasis. Exp Cell Res. 210 (1994b) 1-9. 

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