Metallomics nuclear-based

Nuclear-based Metallomics in Metal-based Drugs... 

Nuclear-based Metallomics in Metallic Nanomaterials Nanometallomics... 

For the determination of the metallome structure, different nuclear-base techniques can be applied, like X-ray crystallography and solution structure determination by multi-dimensional nuclear magnetic resonance (NMR). Other techniques capable of offering the data mainly include Mossbauer spectroscopy, X-ray absorption spectrometry (XAS), and electron paramagnetic resonance (EPR), and neutron scattering. However, in the structural analysis of nanometallome, XAS is the most often used techniques through literature. 

Techniques such as ray-based techniques and nuclear magnetic resonance (NMR) can be used for the structural characterization of metallomes and metalloproteome. Ray-based techniques can characterize the structure at the atomic level. Rays that can be used for structural analysis include X-rays, gamma rays, or neutron beams. 

This book is written by experts from disciplines as diverse as analytical chemistry, nuclear chemistry, environmental science, molecular biology, and medicinal chemistry in order to identify potential hot spots of metallomics and metalloproteomics. The scientific fundamentals of new approaches, like isotopic techniques combined with ICP-MS/ESI-MS/MS, the synchrotron radiation-based techniques. X-ray absorption spectroscopy, X-ray diffraction, and neutron scattering, as well as their various applications, with a focus on mercury, selenium, chromium, arsenic, iron and metal-based medicines are critically reviewed, which can help to understand their impacts on human health. The book will be of particular interest to researchers in the fields of environmental and industrial chemistry, biochemistry, nutrition, toxicology, and medicine. Basically, the book has two aims. The first deals with the educational point of view. Chapters 2 to 7 provide the basic concept of each of the selected nuclear analytical techniques and should be understandable by Master and PhD students in chemistry, physics, biology and nanotechnology. The... 

Nuclear analytical techniques include different methods for elemental analysis which are based on nuclear processes or simply employ nuclear instrumentation. The common feature is the use of sophisticated, highly developed equipment which has great versatility and therefore is able to cope with the specific requirements of the field of application. Metallomics is a subject receiving great attention as a new frontier in the investigation of trace elements... 

As a key lab of Chinese Academy of Sciences, most of the important nuclear analytical techniques are available and also open to external users from various disciplines. In addition, the synchrotron radiation facility in our institute provides useful beamlines for metallomics and metalloproteomics-related researches. Therefore, based on these convenient conditions, we have developed related methodology and application over the past 20 years. In this book, we outline our main achievements and current progress in the metallomics and metalloproteomics on several important elements (Hg, Se, As, REEs, etc) and nanomaterials made within the last 10 years. 

Yuxi Gao is an associate professor at Institute of High Energy Physics, Chinese Academy of Sciences. He obtained his PhD degree in environmental sciences in 2000 from Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences. His current research focuses on the methodology of metallomics and metallo-proteomics based on the nuclear analytical techniques the applications of metallomics and metalloproteomics tourniquets on the environmental and biomedical research the homeostasis of trace elements and their regulatory mechanism the structure, function and structure-function relationship of important metalloproteins. 

---