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Metabolism hypertrophy

Substantial toxic effects in the liver have been seen in acute studies in animals. Prout et al. (1985) administered single doses of 10-2,000 mg/kg trichloroethylene to rats and mice. Blood level kinetics of trichloroethylene and its metabolites revealed that trichloroethylene was metabolized more quickly in the mouse, and thus, at high doses, the mouse was exposed to greater concentrations of trichloroethylene metabolites than the rat. Hepatic hypertrophy and centrilobular swelling were observed in mice treated with... [Pg.87]

Hepatic peroxisome proliferation, characterized by liver enlargement due to hyperplasia and hypertrophy, has been proposed as a basis for differences in species susceptibility to trichloroethylene carcinogenicity. Peroxisomes are membrane-bound organelles which contain enzymes generally involved in lipid metabolism. [Pg.135]

Testosterone metabolism. The lipido-ste-rol extract (LSESr, Permixon) was studied in primary cultures of epithelial cells and fibroblasts separated from benign prostate hypertrophy and prostate cancer tissues. The extract inhibited the formation of the T metabolites androstenedione 5 4 and 5 a-DHT The lipophilic extracts of fruits inhibited T 5p-reductase (EC 1.3.99.5) (5(xR). For fatty acid-like 5(xR inhibition a strongly polar end-group and a molecular skeleton allowing nonpolar interactions with the enzyme were required. The result indicated that 5pR activity in prostatic tissue may be influenced by the lipid environ-... [Pg.477]

Increased metabolism or elimination of the chemical by liver enzymes, such as occurs in rats when thyroid hormone ( , T4) elimination is enhanced, resulting in a compensatory increase in thyroid-stimulating hormone (TSH) and thyroid hypertrophy. [Pg.502]

The growth of animals can be defined as an increase in mass of whole body, tissue(s), organ(s), or cell(s) with time. This type of growth can be characterized by morphometric measurements eg, skeletal muscle or adipose tissue growth can be described by observing temporal changes in cell number, ie, hyperplasia, and cell size, ie, hypertrophy. Growth also includes developmental aspects of function and metabolism of cells and tissues from conception to maturity. [Pg.408]

The azasteroids 268 and 269 of potential clinical utility for the treatment of acne, hirsutism or prostatic hypertrophy, have been 14C-labelled in ring A and the t-butyl portion of carboxamide for metabolism and bioavailability studies283. [Pg.988]

Iguchi H, Ikeuchi T, Kai Y, Yoshida H. [Influence of antiandrogen therapy for prostatic hypertrophy on lipid metabolism.jHinyokika Kiyo 1994 40(3) 215—9. [Pg.295]

The effects of chronic hypertension on the human organism are, with one exception, of little interest to the investigator studying pathogenesis, although of great import to the sufferer and his physician. That exception is failure of the kidneys. Disease and failure of the heart are probably caused by chronic overstrain, often associated with another metabolic disease, arteriosclerosis of the coronary arteries. They account for about two thirds of the deaths primarily due to hypertension. Strokes of apoplexy, or cerebral vascular accidents, from rupture or thrombosis of a cerebral artery weakened by disease cause another sixth, uremia about one twelfth, and other conditions the remainder (28). Except for uremia, these events are usually the result of overwork and increased arterial tension. Only rarely does the heart escape hypertrophy. [Pg.3]

In the rodent, frequently a dose-related increase of the liver weight paralleled by hepatocytic hypertrophy occurs. This phenomenon is often due to induction of hepatic drug metabolizing enzymes. It is obviously over-expressed in the rodent species with the aim to faster metabolise xenobiotics and also degradation... [Pg.787]

Specific exercise such as weightlifting can increase muscle mass (9,10). While the potential to develop muscle mass is established, the metabolic changes that lead to these changes remain unclear. Relatively few studies have examined amino acid metabolism during exercise-induced hypertrophy. The primary reason for the lack of information is the absence of a convenient animal model for weightlifting studies. Human studies utilizing nonradioactive, stable isotopes have not yet been done. [Pg.46]

Cardiovascular Disorders and Copper. Sudden cardiac failure has been associated with copper deficiency (91J. There are two attractive mechanisms. First, the coronary arteries and aorta may become weakened from an inability to synthesize elastin due to a decrease in lysyl oxidase activity. Rupture of these major blood vessels has been shown to cause sudden death in animals suffering from copper deficiency. Second, a decrease in cytochrome oxidase activity during copper deficiency Impairs aerobic metabolism of the heart and increases the risk of hypertrophy. Hypertrophy, which may lead to high output congestive heart failure, is exacerbated by hypochromic anemia also caused by copper deficiency. [Pg.101]

Other adverse reactions to insulin are lipodystrophy (atrophy or hypertrophy) at the injection sites (rare with purified pork and human insulin), after they have been used repeatedly. These are unsightly, but otherwise harmless. The site should not be used further, for absorption can be erratic, but the patient may be tempted to continue if local anaesthesia has developed, as it sometimes does. Lipoatrophy is probably allergic and lipohypertrophy is due to a local metabolic action of insulin. Local allergy also is marrifested as itching or painful red lumps. [Pg.686]


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See also in sourсe #XX -- [ Pg.37 ]




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