Prostate cancer tissue

Hood BL, Darfler MM, Guiel TG, et al. Proteomic analysis of formalin-fixed prostate cancer tissue. Mol. Cell. Proteomics 2005 4 1741-1753. 

Testosterone metabolism. The lipido-ste-rol extract (LSESr, Permixon) was studied in primary cultures of epithelial cells and fibroblasts separated from benign prostate hypertrophy and prostate cancer tissues. The extract inhibited the formation of the T metabolites androstenedione 5 4 and 5 a-DHT The lipophilic extracts of fruits inhibited T 5p-reductase (EC 1.3.99.5) (5(xR). For fatty acid-like 5(xR inhibition a strongly polar end-group and a molecular skeleton allowing nonpolar interactions with the enzyme were required. The result indicated that 5pR activity in prostatic tissue may be influenced by the lipid environ-... 

Yousef GM, Scorilas A, Chang A, et al. Down-regulation of the human kallikrein gene 5 (KLK5) in prostate cancer tissues. Prostate 2002 51 126-132. 

P3. Pasquali, D., Thaller, C., and Eichele, G., Abnormal level of retinoic acid in prostate cancer tissues. J. Clin. Endocrinol. Metab. 81, 2186-2191 (1996). 

Genistein and daidzein directly affect testosterone metabolism, reducing the toxic metabolites of testosterone. Genistein, an isoflavone, also seems to slow or prevent the metastasis of invasive cancer cells. It is believed to work by preventing the formation of new blood vessels to cancerous tumors. Histoculture studies of genistein have shown that this phytochemical reduces the growth of prostatic cancer tissue. 

Aslan G, Irer B, Tuna B, et al. Analysis of NKX3.1 expression in prostate cancer tissues and correlation with clinicopathologic features. Pathol Res Pract. 2006 202 93. 

Van de Sande, T., Roskams, T., Lerut, E., Ionian, S., Van Poppel, H., Verhoeven, G. and Swinnen, J. V., High-level expression of fatty acid synthase in human prostate cancer tissues is linked to activation and nuclear localization of Akt/PKB, J Pathol 206 (2005) 214-219. 

The author thanks The Cooperative Prostate Cancer Tissue Resource. 

Berman, J. J., M. Datta, A. Kajdacsy-Balla, J. Melamed, J. Orenstein, K. Dobbin, A. Patel, R. Dhir, and M. J. Becich. 2004. The tissue microarray data exchange specification Implementation by the Cooperative Prostate Cancer Tissue Resource. BMC Bioinformatics 5 19. 

Rentala S, Mangamoor LN. Isolation, characterization and mobilization of prostate cancer tissue derived CD133-H MDRl-t cells. J Stem Cells. 2010 5 75-81. 

Eberlin, L.S., Dill, A.L., Costa, A.B., Ifa, D.R., Cheng, L., Masterson, T., Koch, M., Rathff, T.L., Cooks, R.G. (2010) Cholesterol sulfate imaging in hnman prostate cancer tissue by desorption electrospray ionization mass spectrometry. Anal. Chem., 82(9), 3430-3434. 

S. Reeve, C. A. Hart, M. D. Brown and N. W. Clarke, A Correlation of FTIR Spectra Derived From Prostate Cancer Tissue with Gleason Grade and Tumour Stage, Eur. Urol., 2006, 50, 750-761. 

Gazi, E. et al (2006) A correlation of FTIR spectra derived from prostate cancer tissue with gleason grade, psa and tumour stage. Ear. Urol, 50, 750—761. 

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