Metabolic reprogramming metabolism

Mechanism of Action Lithium s pharmacologic mechanism of action is not well understood and probably involves multiple effects. Possibilities include altered ion transport, increased intraneuronal catecholamine metabolism, neuroprotection or increased brain-derived neurotrophic factor, inhibition of second messenger systems, and reprogramming of gene expression.29... 

Naoumkina MA, He XZ, Dixon RA (2008) Ehcitor-induced transcription factors for metabolic reprogramming of secondary metabolism in Medicago truncatula. BMC Plant Biol 8 132... 

Runguphan W, O Connor SE. (2009) Metabolic reprogramming of periwinkle plant culture. Nat Chem Biol 5 151-153. 

Batz O, Logemann E, Reinold S, Hahlbrock K. 1998. Extensive reprogramming of primary and secondary metabolism by fungal elicitor or infection in parsley cells. Biol Chem 379 1127-1135. 

Reprogramming the central metabolism, if necessary, to supply the required redox equivalents and metabolic energy, usually in the form of ATP. 

The future generation of bioflavors could involve reprogramming of metabolic pathways in microbes and plants to arrive at novel or improved flavor top notes or building blocks. In most cases the pathways and the enzymes involved in flavor biogenesis are not known and hence, it is currently impossible to over-express such pathways by genetic tools [104],... 

Trinh, C.T. (2012) Elucidating and reprogramming Escherichia coli metabolisms for obligate anaerobic n-butanol and isobutanol production. Appl Microbiol Biotechnol, 95, 1083-1094. 

Trinh, C.T. and Thompson, R.A. (2012) Elementary mode analysis a useful metabolic pathway analysis tool for reprograming microbial metabolic pathways, in Reprogramming Microbial Metabolic Pathways, Vol. 64 (eds X. Wang, J. Chen, and P. Quinn), Springer Netherlands, Dordrecht, pp. 21 -42. 

The poly(ADP-ribose) metabolism arising from the cooperation of PARP-1 and PARC is involved in DNA base excision repair and in DNA dama s naling to cell survival/cell death pathways. The present review focuses on a particular aspect of poly(ADP-ribose) signaling when PARP-1 is activated, it catalyzes poIy(ADP-ribose) synthesis on itself ( automodification). The polymers on PARP-1 can then recruit other proteins into multiprotein complexes and reprogram their domain functions. 

Metabolic Reprogramming Enhancing the Mitochondrial Metabolism in Cancer Cells... 

Metabolic reprogramming in cancer cells, specially drug-resistance cells, by combination of DCA and anti-cancer alkaloids is currently an unexplored area. Several anti-cancer alkaloids that affeet mitochondrial respiration (e g., berberine and lamellarin-D) or induce... 

Figure 7. PDK/PDH axis and metabolic reprograrnming in cancer cells. PDH activity is controled by PDK and PDP. When PDH is active, pyruvate (produced by glycolysis ) is converted in Acetyl-CoA, which is used in TCA cycle and OXPHOS, increasing mitochondrial metabolism. In contrast when PDH is inactive, pyruvate is converted in lactate and mitochondrial metabolism, specially OXPHOS, is decreased. In this case, ATP demand is supplied by glycolysis in cancer cells. PDK inhibition by dichloroacetate (EX7A ) produces metabolic reprogramming toward mitochondrial metabolism, which increases OXPHOS and restores the sensitivity to anti-cancer compounds with mitochondrial targets.

Y. W. Choi, and I. K. Lim, Sensitization of metformin -cytotoxicity by dichloroacetate via reprogramming glucose metabolism in cancer cells. Cancer Lett., 346 (2014) 300-8. 

Mitsuishi, Y, K. Taguchi, Y. Kawatani, T. Shibata, T. Nukiwa et al. 2012. Nrf2 redirects glucose and glutamine into anabolic pathways in metabolic reprogramming. 

The process of acquisition of embryogenic competence by somatic cells must involve reprogramming of gene exptression patterns as well as changes in the morphology, physiology, and metabolism (Namasivayam, 2007). These alterations reflect dedifferentiation, activation of cell division and a change in cell fate. 

Seiboth B, Herold S, Kubicek CP. (2012). Metabolic engineering of inducer formation for ceUulase and hemicellulase gene expression in Trichoderma reesei. In Wang X, Chen J, Quinn P, editors. Reprogramming Microbial Metabolic Pathways. New York Springer, pp. 367-390. 

Bernhardt P, McCoy E, O Connor SE (2007) Rapid identification of enzyme variants for reengineered alkaloid biosynthesis in periwinkle. Chem Biol 14 888-897 Runguphan W, O Connor SE (2009) Metabolic reprogramming of periwinkle plant culture. Nat Chem Biol 5 151-153... 

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