Big Chemical Encyclopedia

Chemical substances, components, reactions, process design ...

Articles Figures Tables About

Metabolic reprogramming

Naoumkina MA, He XZ, Dixon RA (2008) Ehcitor-induced transcription factors for metabolic reprogramming of secondary metabolism in Medicago truncatula. BMC Plant Biol 8 132... [Pg.177]

Runguphan W, O Connor SE. (2009) Metabolic reprogramming of periwinkle plant culture. Nat Chem Biol 5 151-153. [Pg.647]

Metabolic Reprogramming Enhancing the Mitochondrial Metabolism in Cancer Cells... [Pg.18]

Metabolic reprogramming in cancer cells, specially drug-resistance cells, by combination of DCA and anti-cancer alkaloids is currently an unexplored area. Several anti-cancer alkaloids that affeet mitochondrial respiration (e g., berberine and lamellarin-D) or induce... [Pg.18]

Figure 7. PDK/PDH axis and metabolic reprograrnming in cancer cells. PDH activity is controled by PDK and PDP. When PDH is active, pyruvate (produced by glycolysis ) is converted in Acetyl-CoA, which is used in TCA cycle and OXPHOS, increasing mitochondrial metabolism. In contrast when PDH is inactive, pyruvate is converted in lactate and mitochondrial metabolism, specially OXPHOS, is decreased. In this case, ATP demand is supplied by glycolysis in cancer cells. PDK inhibition by dichloroacetate (EX7A ) produces metabolic reprogramming toward mitochondrial metabolism, which increases OXPHOS and restores the sensitivity to anti-cancer compounds with mitochondrial targets. Figure 7. PDK/PDH axis and metabolic reprograrnming in cancer cells. PDH activity is controled by PDK and PDP. When PDH is active, pyruvate (produced by glycolysis ) is converted in Acetyl-CoA, which is used in TCA cycle and OXPHOS, increasing mitochondrial metabolism. In contrast when PDH is inactive, pyruvate is converted in lactate and mitochondrial metabolism, specially OXPHOS, is decreased. In this case, ATP demand is supplied by glycolysis in cancer cells. PDK inhibition by dichloroacetate (EX7A ) produces metabolic reprogramming toward mitochondrial metabolism, which increases OXPHOS and restores the sensitivity to anti-cancer compounds with mitochondrial targets.
Mitsuishi, Y, K. Taguchi, Y. Kawatani, T. Shibata, T. Nukiwa et al. 2012. Nrf2 redirects glucose and glutamine into anabolic pathways in metabolic reprogramming. [Pg.401]

Bernhardt P, McCoy E, O Connor SE (2007) Rapid identification of enzyme variants for reengineered alkaloid biosynthesis in periwinkle. Chem Biol 14 888-897 Runguphan W, O Connor SE (2009) Metabolic reprogramming of periwinkle plant culture. Nat Chem Biol 5 151-153... [Pg.250]

Metabolic Reprogramming Under Microaerobic and Anaerobic Conditions in Bacteria... [Pg.159]

Key Factors That Govern the Metabolic Reprogramming of Bacteria in Response to... [Pg.160]

Two major requirements govern the metabolic reprogramming for facultative bacteria in response to different levels to achieve optimal energy conservation and to maintain the cellular redox homeostasis. Under aerobic growth conditions, facultative... [Pg.160]

Application and Manipulation of Anaerobic Metabolic Reprogramming in Biotechnology... [Pg.170]

P S. Ward, C.B. Thompson, Metabolic reprogramming a cancer hallmark even Warburg did not anticipate. Cancer Cell 21 (2012) 297-308. [Pg.26]

See other pages where Metabolic reprogramming is mentioned: [Pg.335]    [Pg.634]    [Pg.634]    [Pg.634]    [Pg.445]    [Pg.158]    [Pg.1]    [Pg.2]    [Pg.21]    [Pg.395]    [Pg.239]    [Pg.159]    [Pg.160]    [Pg.161]    [Pg.164]    [Pg.168]    [Pg.170]    [Pg.219]    [Pg.225]    [Pg.266]    [Pg.295]   
See also in sourсe #XX -- [ Pg.634 ]



SEARCH



Metabolic reprogramming anaerobic metabolism (

Metabolic reprogramming metabolism)

Metabolic reprogramming metabolism)

Metabolic reprogramming requirements

Reprogramming

© 2024 chempedia.info