Merozoite

G. J. Jennings, A. Belkum, L. van Boom, and M. Wiser, "Analysis of VariabiUty of the Merozoite Surfact Protein of Plasmodian berghei," 44th Annual Meeting of the American Society of Tropical Medicine and Hygiene, San Antonio, Tex., Nov. 17—21,1995. 

C. ruptures the red blood cells diat contain merozoites... 

Plasmodium merozoites surface antigen fragments Outer membrane protein fragments Fusion protein fragments... 

An anopheline mosquito inoculates plasmodium sporozoites to initiate human infection (Figure 52-1). Circulating sporozoites rapidly invade liver cells, and exoerythrocytic stage tissue schizonts mature in the liver. Merozoites are subsequently released from the liver and invade erythrocytes. Only erythrocytic parasites cause clinical illness. Repeated cycles of infection can lead to the infection of many erythrocytes and serious disease. Sexual stage gametocytes also develop in erythrocytes before being taken up by mosquitoes, where they develop into infective sporozoites. 

Sowa, A., Kordai M.P., Cavanagh, D.R., et al. (2001). Isolation of a monoclonal antibody from a malaria patient-derived phage display library recognising the Block 2 region of Plasmodium falciparum merozoite surface protein-1. Mol. Biochem. Parasitol., 112, 143-147. 

Oral administration of polyether antibiotics allows, initially, for regulation of the body function at the site of digestion by positively affecting feed conversion efficiency and negatively affecting the developmental stage of coccidia. Since their activity is directed particularly towards sporozoites and merozoites, the polyethers must be fed continuously to be fully effective but are not recommended for treating established infections. They have a low therapeutic index and may... 

Agents such as quinine, quinacrine, amodiaquine, and chloroquine suppress the symptoms of malaria by destroying the schizonts and merozoites in the erythrocytes. 

Lougovskoi, A.A., Okoyeh, N.J., and Chauhan, V.S. (1999) Mice immunised with synthetic peptide from N-terminal conserved region of merozoite surface antigen-2 of human malaria parasite Plasmodium falciparum can control infection induced by Plasmodium yoeliiyoelii 265BY strain. Vaccine 18(9-10), 920-930. 

Audran, R., Cachat, M Lurati, F., et al. (2005) Phase I malaria vaccine trial with a long synthetic peptide derived from the merozoite surface protein 3 antigen. Infect. Immun. 73(12), 8017-8026. 

The intrinsic life cycle begins when a female mosquito takes a blood meal. At this time, sporozoites that have matured in the mosquito s salivary glands are inoculated into the blood stream. These sporozoites migrate to the liver where they infect hepato-cytes and progress from early trophozoites to mature schizonts. This process is referred to as the exoerythrocytic cycle. Schizonts in the liver contain thousands of merozoites that are able to infect... 

Dvorak JA, Miller LH, Whitehouse WC, Shiroishi T (1975) Invasion of erythrocytes by malaria merozoites. Science 187(4178) 748-750... 

Hossain ME, Dhawan S, Mohmmed A (2012) The cysteine-rich regions of Plasmodium falciparum RON2 bind with host erythrocyte and AMA1 during merozoite invasion. Parasitol Res 110(5) 1711- 1721... 

Interest in vaccine development has centered around the asexual erothrocytic stage of the life cycle, especially the merozoite. Several proteins associated with these stages have been identified and produced by recombinant techniques (92,93). The most prominent is the MSA-1 protein of the merozoite. A clinical trial with this protein is being planned (93). 

Upon release, each merozoite invades red blood cells, using... 

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