Mehta studies

Ghosh, S., T.K. Das, D.B. Datta, and S. Mehta Studies on Enamides Part-1 Photochemical Rearrangement of N-Aroyl Carbazoles. Tetrahedron Letters 28,4611 (1987). 

Mehta studied the electrochemical properties of the Eu 7Eu pair (as triflates) in PEO-based polymer electrolytes. Mehta s main contribution came from cyclic voltammetry studies at a temperature close to 75 °C, which demonstrated that the observed ohmic drop had a large contribution from the low conductivity of the polymer electrolyte. The author concluded, from the characteristics of the peaks corresponding to the Eu + reduction and the Eu + oxidation, that these were situated at electrical potential values close to theoretical values, but the processes did not show reversibility. Impedance studies revealed that the behaviour of the system was controlled by mass transport processes and the respective main role was assigned to the Eu + ion, with a diffusion coefficient of 3.66 x 10" cm s . ... 

Facial selectivities in the nucleophilic addition of bicyclic ketones have recently been examined comprehensively [71, 72]. Mehta and his colleagues studied the facial selectivities of 2,3-exo,exo-disubstituted 7-norbomanones 14a and 14b [73-75]. In the reduction of 14a and 14b with sodium borohydride, lithium aluminum hydride. 

Mehta et al. also studied the facial selectivities of exo-substituted 7-norbomenones 15a and 15b, which exhibit steric bias with respect to the anti side of the n face (with respect to the exo substituent) [76, 77]. In the reduction with sodium borohy-dride, high anti preference (more than 85%) was observed in the parent derivative 15a. Weak electron-withdrawing substituents (CH OCH, CH OAc, COONa) also showed anti preference, the magnitude being comparable to that in the case of the parent compound (15a) this is indicative of the steric bias of 15a. In the case of a strong electron-withdrawing substituent (di- or mono-CO CH, CN), the syn preference of addition was increased, becoming predominant in some cases (di-CO CHj (15b) syn. anti = 55 45 mono-CO CH synianti = 32 68 mono-CN syn anti =... 

Mehta et al. also studied the facial selectivities of 5,6-exo,eji o-disubstituted bicyclo[2.2.2]octan-2-ones 18 [75, 78]. These systems are related to the 2,3-exo,ex( -disubstituted 7-norbomanones 14, but differ in the direction of the carbonyl n face. Hydride reduction of 5,6-exo,ex( -disubstituted bicyclo[2.2.2] octan-2-ones (18) with NaBH and DIBAL-H and methylation with MeLi were smdied [75, 78],... 

AM Mehta, LL Augsburger. A preliminary study of the effect of slug hardness on drug dissolution from hard gelatin capsules filled on an automatic capsule filling machine. Int J Pharm 7 327-334, 1981. 

Goss, D. J., Parkhurst, L. J., Mehta, H. B., Woodley, C. L., and Wahba, A.J. (1984). Studies on the role of eukaryotic nucleotide exchange factor in polypeptide chain initiation. 

In a study which was conducted simultaneously to the work in the Mehta group and which also aimed to prove the absolute configuration of natural kelsoene (1), Schulz et al. used a stereoselective approach starting from the enantiomerically pure chiral pool material (i )-pulegone 17 [9, 10] (see above). The final steps of their synthesis of the unnatural enantiomer of kelsoene (ent-l) were similar to the above-described first total synthesis of natural kelsoene (1) (Scheme 8). Taking into account the steric limitations of the system as communicated by Srinivas and Mehta, diquinane enone ent-6... 

The FDA allows single-dose human studies based on single-dose animal studies. A rodent and non-rodent species are required and signs of major toxicity must be demonstrated. The study design is outlined in the publication by Munro and Mehta and requires an observation period of 14 days after dosing. 

Munro A, Mehta D. Are single-dose toxicology studies in animals adequate to support single doses of new drug in humans Clin Pharmacol Ther 1996 59 258-64. 

Diketone 228, prepared by Mehta in conjunction with another study, has been transformed into 717 in a clever sequence of reactions which required no protection steps The conversion of methanoindene 718 into the highly functionalized intermediate 719 that might be serviceable as a coriolin precursor has been published... 

Ettringite has been widely studied in cement and concrete due to the deleterious expansion, which has been attributed to its formation after the concrete has hardened (Lea 1971 Mehta 1973 Dunstan 1980 Cohen 1983 Monteiro Mehta 1985 Tikalsky 1989 Day 1992 Tishmack et al. 1999). Ettringite also causes expansion in some types of high-S CCPs (see below). 

For example, the UHT heat treatment results in some protein dena-turation, but the biological value and net utilization of milk proteins remain essentially unaffected (Katz et al. 1981 Ford and Thompson 1981 Mehta 1980). In fact, UHT milk may be more digestible than raw or conventionally pasteurized milk because of the greater protein denaturation. The results of both animal feeding studies and studies of human infants indicate that the protein utilization of UHT milk is at least as high as that of conventionally pasteurized milk (Renner 1980 Katz et al. 1981). 

In addition, Mehta et al. present a case study of Shell s Popeye field use of a new AA inhibitor in a gas condensate line, with the following points ... 

Cakiryildiz, C., Mehta, P.J., Rahmen, W., and Schoenleber, D. (1975). Dissolution studies with a multichannel continuous- owapparatufe,Pharm. Sci., 64, 1692-1697. 

Battifora, H., Gaffey, M., Esteban, J., Mehta, R, Bailey, A., Faucett, C., and Niland, J. 1991. Immunohistochemical assay of neu/c-erbB-2 oncogene product in paraffin-embedded tissues in early breast cancer Retrospective follow-up study of 245 stage I and II cases. Mod. Pathol. 4 466-414. 

Mehta AC, Dawson-Butterworth K, Woodhouse MA. 1966. Argyria. Electron microscopic study of a case. Br J Dermatol 78 175-179. 

Recently, there has been a marked development in the methodologies to observe and manipulate single biopolymers (Mehta et al., 1999 Arai et al., 1999 Cui and Bustamante, 2000 Liphardt et al., 2001). The key procedure in the successful manipulation of single biopolymers has been the tight attachment of the end of the polymer to a micrometer-sized object. To achieve a wider application of such single-molecular technology, it would be important to manipulate individual macromolecules and control their conformation without any structural modifications (Chiu and Zare, 1996 Brewer et al., 1999). Thus, the manipulation of the compact DNAs without the attachment to a micrometer-sized bead or to any other macroscopic objects is expected to be useful for micrometer-scale laboratory experiments. This manipulation will also be a powerful tool for lab-on-a-chip or lab-on-a-plate (Katsura et al., 1998 Yamasaki et al., 1998 Matsuzawa et al., 1999, 2000). It may of value to refer to a recent study in transporting a compact DNA into a cell-sized liposome (Nomura et al., 2001). 

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