Meglumine

Chemical Name 3-(Acetylamino)-2,4,6-triiodo-5-[(methylamino)carbonyl] -benzoic acid Common Name — 

Trade Name Manufacturer Country Year Introduced 

5-Amino-2,4,6-triiodo-N-methylisophthalamic acid Acetic anhydride N-methyl glucamine 

Crude 5-amino-2,4,6-triiodo-N-methylisophthalamic acid (21.0 g) was dissolved in warm di-methylacetamide (40 ml) and acetic anhydride (30 ml) and concentrated sulfuric acid (2 drops) were added. This solution was heated on the steam bath for 2 hours, then heated at 110°C for 5 minutes, then cooled. Water and ammonium hydroxide were added to destroy the excess acetic anhydride, after which the mixture was evaporated to a volume of 50 ml. The cooled solution was acidified with concentrated hydrochloric acid and a tan solid was collected. The crude product was dissolved in 100 ml of water containing a slight excess of sodium hydroxide. The pH was adjusted to 4.5 with acetic acid, and the solution was treated with charcoal. The colorless solution was acidified with concentrated hydrochloric acid and 

5-acetamido-2,4,6-triiodo-N-methylisophthalamic acid was slurried in water and dissolved by the addition of an equivalent quantity of N-methylglucamlne. The solution was evaporated to dryness to yield the meglumate selt of 5-acetamido-2,4,6-triiodo-N-methylisophthalamic acid. 

Patent 3,145,197 August 18,1964 assigned to Mallinckrodt Chemical Works 

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Extravasation of barium sulfate iato the peritoneal cavity through a perforated GI tract can produce serious adverse reactions. When a perforation is suspected, the use of a water-soluble iodinated contrast medium is iadicated. In this case, oral or rectal administration of sodium or meglumine-sodium salts of diatrizoic acid (6) and oral use ofiohexol (11) are the preferred procedures. 

Meglumine [6284-40-8] antimonate [133-51 -7] C H NO HO Sb, (Glucantime) is a pentavalent antimonial used for the treatment of leishmania sis in Latin America (207) and in the French-speaking areas of Europe and Africa (206). It is adrxiinistered by deep intramuscular injection. Although relatively safe and usually well tolerated, numerous side effects have been observed. It is not available in the United States. 

Meglumine Salt Biligram Biligram Biligram Billvistan Rayvist... 

A mino-2,4,6-tri iodo-N-methyl iso-phthalamic acid lothalmate meglumine... 

Ionic contrast media are triiodobenzene derivatives carrying a negative electrical charge, water soluble only as sodium or meglumine (an organic cation similar to glucosamine) salts. 

Hypaque Sodium (Winthrop) wfm Meglumine Diatrizoale (Squibb) wfm... 

CN 3-(acetylamino)-5-[(acetylamino)methyl]-2,4,6-triiodobenzoic acid meglumine salt... 

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