Meglumine diatrizoate

Reticulated purpura has been reported after the use of diatrizoate meglumine, a high-osmolar water-soluble contrast agent, for hysterosalpingography (212). 

Recently, minute doses of nonradioactive filtration markers such as iothalamate and diatrizoate meglumine (or Hypaque) have been used for assessing GFR. The development of high-performance liquid chromatography procedures for measurement of these nonradioactive filtration markers in plasma and urine provides a practical alternative to the laboratorian wary of the hazards associated with a radiolabel. 

Angiovist 282, Hypaque Meglumine 60%, Reno-M-60) (Diatrizoate Meglumine 76%)... 

To obtain a more pure population of A. phagocytophilum, organisms can be isolated from host cell debris using a number of techniques see Note 9). The most common protocol uses diatrizoate meglumine. This technique was first described for the Rickettsiae in 1981 and has been modified over time by a number of investigators (9,10,11,12) see Note 10). 

Iannaccone et al. (2004) examined successfully 203 patients with laxative-free CT colonography. They performed faecal tagging over two days with a total of 200 ml of diatrizoate meglumine and diatrizoate sodium. The patients were also on a low residue diet for two days. They obtained very good results of polyp detection 86% for lesions >6 mm (79 lesions), 95.5% for lesions >8 mm (45 lesions), 100% for lesions >1 cm (24 lesions). 

Callstrom et al. (2001) performed laxative-free CT colonography without dietary restrictions in 58 patients. Faecal tagging was obtained with a combination of iodine and barium administered over one or two days. The best results of tagging were obtained by combining 6x225 ml of a 2.1% w/v barium suspension and 1x225 ml dilute diatrizoate meglumine and diatrizoate sodium. All residue with a density >150 H.U. was electronically labelled. In that way a 100% sensitivity for lesions >1 cm was obtained (5/5 lesions). 

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