Pharmacokinetics flunixin meglumine

Blythe L L, Craig A M, Christensen J M et al 1986 Pharmacokinetic disposition of dimethyl sulfoxide administered intravenously to horses. American Journal of Veterinary Research 47 1739-1743 Bottoms G D, Fessler J F, Roesel O F et al 1981 Endotoxin-induced hemodynamic changes in ponies effects of flunixin meglumine. American Journal of Veterinary Research 42 1514-1518... 

In horses, the pharmacokinetics of flunixin meglumine has been well defined. Flunixin meglumine, at the recommended dose of 1.1 mg/kg, has a short plasma half-life of approximately 1.5-3h. It persists in inflammatory exudates for much longer, however, with an exudate half-life of approximately 16 h (Landoni Lees 1995a, Soma et al 1988). Renal excretion of the parent compound seems to be the primary mode of elimination of flunixin meglumine in horses (Lees Higgins 1985). 

The pharmacokinetics of flunixin meglumine has also been studied in foals. In neonatal foals. 

Galbraith L A, McKellar Q A 1996 Protein binding and in vitro serum thromboxane B2 inhibition by flunixin meglumine and meclofenamic acid in dog, goat and horse blood. Research in Veterinary Science 61 78-81 Gerring E L, Lees P, Taylor J B 1981 Pharmacokinetics of phenylbutazone and Its metabolites in the horse. Equine Veterinary Journal 13 152-157 Glaser K, Sung M L, O Neill K et al 1995 Etodolac... 

Zertuche, J.M.L., Brown, M.P., Gronwall, R. Merritt, K. (1992) Effect of probenecid on the pharmacokinetics of flunixin meglumine and phenylbutazone in healthy mares. American Journal of Veterinary Research, 53, 372-374. 

Crisman, M.V., Wilcke, J.R. Sams, R.A. (1996) Pharmacokinetics of flunixin meglumine in healthy foals less than twenty-four hours old. American Journal of Veterinary Research, 57,1759-1761. 

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