Drug interactions adverse

Evaluate the medication regimen for drug interactions, adverse reactions, and allergies. 

Keywords Pharmacokinetics Pharmacodynamics Drug-drug interactions Adverse drug reactions... 

D Arcy PF. Adverse reactions and interactions with herbal medicines. Part 2. Drug interactions. Adverse Drug React Toxicol Rev 1993 12 147-162. 

Consider the difference in response to drugs between older and younger people. Treatment should reflect biological age (rather than chronological). Pharmacokinetics, pharmacodynamics, tolerability, adverse reactions, economy and patient choice will all influence therapy chosen. Most commonly, car-bamazepine or sodium valproate are chosen for older people as their effects in older people are well documented. Both show a favourable balance of safety, efficacy and economy. Phenytoin is less preferable because of drug interactions, adverse effects and potential for toxicity (zero order kinetics). 

Drug interactions Adverse effects of concurrent medications may be synergistic or cumulative with those associated with opioids. 

Drug-drug interaction Adverse drug reaction when a second drug modifies the way the body handles or reacts to the first agent. 

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