Medial

TABLE 4.4 The kinetics of nitration of nitrobenzene in various medial... 

Two AT-II receptors, AT and AT2 are known and show wide distribution (27). The AT receptor has been cloned and predominates ia regions iavolved ia the regulation of blood pressure and water and sodium retention, eg, the aorta, Hver, adrenal cortex, and ia the CNS ia the paraventricular nucleus, area postrema, and nucleus of the soHtary tract. AT2 receptors are found primarily ia the adrenal medulla, utems, and ia the brain ia the locus coeruleus and the medial geniculate nucleus. AT receptors are GCPRs inhibiting adenylate cyclase activity and stimulating phosphoHpases C, A2, and D. AT2 receptors use phosphotyrosiae phosphatase as a transduction system. 

In the knee, the menisci form an interarticular fibrocartilage base for femural and tibial articulation. The menisci form a crescent shape in the knee. The lateral meniscus is located on the outer side of the knee, and the medial meniscus is located on the inside of the knee. If the knee bends and twists the menisci can overstretch and tear. Menisci tears occur frequentiy and the knee can sustain more than one tear at a time. If not treated appropriately, however, a menisci tear can roughen the cartilage and lead to arthritis. A meniscus tear acts like grit in the ball bearings of a machine. The longer the torn tissue remains affected, the more irritation it causes. 

A typical physical-chemical treatment system incorporates three "dual" medial (sand anthracite) filters connected in parallel in its treatment train. The major maintenance consideration with granular medial filtration is the handling of the backwash. The backwash will generally contain a high concentration of contaminants and require subsequent treatment. 

FIGURE 5.15 Cross-section of human nasal turbinates at various positions along the airway. Distances indicated are from the nares. The medial surface in each cross-section represents the nasal septum. (Modified from Guilmette et al. )... 

Poor blood supply in the area of the medial femoral neck (as the consequence of a pre-existing pathological condition or excessive early weight bearing) leads to initial loosening of the cement bond ... 

Resorption of bone in the medial neck places the forces of continued weight bearing on the bone cement in that area and may lead to medial and/or distal migration of the femoral cement and prosthetic component ... 

Fracture of cement transversely near the distal end of the prosthetic stem or in the area of the medial neck results in a slight downward or medial shift of stem position and further increases the forces upon the stem ... 

Sites of endothelin-receptor expression. ETA receptors are expressed in the smooth muscle cells of the vascular medial layer and the airways, in cardiac myocytes, lung parenchyma, bronchiolar epithelial cells and prostate epithelial cells. ETB receptors are expressed in endothelial cells, in bronchiolar smooth muscle cells, vascular smooth muscle cells of certain vessels (e.g. saphenous vein, internal mammary artety), in the renal proximal and distal tubule, the renal collecting duct and in the cells of the atrioventricular conducting system. 

The raphe nuclei are a cluster of nuclei found in the brainstem, where they are located in the medial portion of the formatio reticularis, the raphe. (The raphe is the junction of the left and right brainstem hemisphere, hence the name raphe=seam). Serotonergic nerve cells in the CNS originate from the raphe nuclei, i.e., their rostral portion, and because of their wide-ranging projections appear to supply serotonin (5HT) to the rest of the brain. 

The temporal lobe is the inferior middle portion of the cerebral cortex of both hemispheres. The temporal lobes are involved in the analysis of visual and acoustic information and in memory formation. The hippocampus is part of the inner, medial side of the temporal lobes. 

The skin is usually degreased with alcohol followed by a mild acetone scrub. After cleaning, Jessner s solution is appUed to the face with a sable brush, cotton tipped apphcators, cotton balls, or 2 X 2 gauze sponges. The author prefers the use of cotton tipped applicators. Typically, the cheeks are treated first, working from medial to lateral areas followed by application to the chin and forehead area. For superficial peeling, two coats are usually applied. Additional coats increase the depth of peeling. 

Fig. 8.1 Rostrocaudal neuroanatomical distribution of CCR5-immunoreactivity in the telencephalon, diencephalon and mesencephalon using a CCR5 antibody (Santa Cruz Biotechnology, Santa Cruz, CA, USA). Regions corresponding to pictures are depicted in coronal diagrams taken from the Paxinos and Watson (1998). (a, b) M Motor cortex, (c, d) CPu caudate putamen (striatum), (e,t)SID substantia innominata dorsal part, (g, h) GP globus pallidus, (i, j)Me medial amygdaloid...

Figure 7.1 Dopamine neuronal pathways. AMYG, amygdala CN, caudate nucleus MFB, medial forebrain bundle NcA, nucleus accumbers OT, olfactory tubercle PUT, putamen SN, substantia nigra. For full details see text and Moore and Bloom (1978) and Lindvall and Bjorkland (1978)...

Figure 7.5 Rate recording of the dose-dependent inhibitory effects of apomorphine (pg/kg) on the spontaneous activity of a neuron in the medial prefrontal cortex of the halothane anaesthetised rat and its antagonism by haloperidol (HAL, 0.5mg/kg). Time scale is 50 min intervals. Reproduced by permission from Dailey (1992)...

In other brain areas which receive a DA input, such as the nucleus accumbens and prefrontal cortex, it appears to be inhibitory and predominently D2-mediated. This is clear from Fig. 7.5 which shows inhibition by apomorphine (mixed D2, Di agonists) of the firing of neurons in the medial prefrontal cortex of the anaesthetised rat and its antagonism by the D2 antagonist haloperidol. 

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