Medial septum cholinergic neurons

Hagg, T., Fass, H. B., Vahlsing, H. L., Manthorpe, M., Conner, J. M., and Varon, S., Nerve growth factor (NGF) reverses axotomy-induced decreases in choline acetyl-transferase, NGF receptor and size of medial septum cholinergic neurons, Brain Res., 505,29, 1989. 

The development of antibodies against ChAT allowed the distribution of neurons producing acetylcholine in the nervous system to be revealed (Mesulam et al., 1983 Armstrong et al., 1983 Jones Beaudet, 1987 Vincent Reiner, 1987). In the context of control of wakefulness and REM sleep two groups of cholinergic neurons are of primary importance. Neurons located in the basal forebrain and medial septum provide the cholinergic innervation of the cerebral... 

Cholinergic neurons in the basal forebrain and medial septum selectively express the low affinity (p75) receptor for nerve growth factor which allows them... 

Recently, E2-CDS also was shown to provide encouraging neuroprotective effects. In ovariectomized rats, pretreatment with E2-CDS decreased the mortality caused by middle cerebral artery (MCA) occlusion from 65-16% [129], Even when administered 40 or 90 min after MCA occlusion, E2-CDS reduced the area of ischemia by 45-90% or 31%, respectively. Another recent study provided evidence that treatment with E2-CDS can protect cholinergic neurons in the medial septum from lesion-induced degeneration [130],... 

Mandel, R. J. et al. (1999b). Nerve growth factor expressed in the medial septum following in vivo gene delivery using a recombinant adeno-associated viral vector protects cholinergic neurons from fimbria-fornix lesion-induced degeneration. Exp. Neurol. 155 (1), 59-64. 

O Brien, T. S., Svendsen, C. N., Isacson, O., and Sofroniew, M. V., Loss of true blue labelling from the medial septum following transection of the fimbria-fornix evidence for the death of cholinergic and non-cholinergic neurons, Brain Res., 508,249,1990. 

Huh CYL, Danik M, Manseau F, Trudeau L-E, WiUiams S (2008) Chronic exposure to nerve growth factor increases acetylcholine and glutamate release from cholinergic neurons of the rat medial septum and diagonal band of Broca via Mechanisms mediated by p75 . 1 Neurosci 28 1404-1409. 

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