Medial arterial calcification

Markello TC, Pak LK, St HC et al (2011) Vascular pathology of medial arterial calcifications in NT5E deficiency implications for the role of adenosine in pseudoxanthoma elasti-cum. Mol Genet Metab 103 44-50... 

Morbus Monckeberg (medial arterial calcification) or medial calcinosis is the deposition of hydroxyapatite (Ca5(P04)30H) in the media. Most frequently affected are the small to medium sized arteries of the lower extremities, the pelvic arteries and the abdominal aorta. An occurrence in the coronary arteries is rare. As a rule, Morbus Monckeberg frequently coincides with atherosclerosis. At an advanced stage, the media is almost entirely replaced by a homogeneous calciferous layer, which displays itself in the computer tomogram almost like a second skeleton (Rg. 5.143). In contrast to atherosclerosis, lipids do not contribute to the deposition. [355]... 

Lehto S, Niskanen L, Suhonen M, Ronnemaa T, Laakso M. Medial artery calcification. A neglected harbinger of cardiovascular complications in non-insulin-dependent diabetes meUitus, ArteriosclerThromb Vase Biol 1996 16 978-983. 

The underl5ung cause of most cases of cardiovascular disease is atherosclerosis [3]. This term describes the stenotic type of atherosclerotic disease in which fatty ( atheromatous ) deposits are formed in the intimal layer of the larger elastic arteries and certain muscular arteries, and interfere with blood flow. Further consequences of this process are fibrosis and calcification of the subintimal and medial layers, and in the narrowed lumen, the growing possibility of thrombosis, leading to total occlusion. 

Vitamin D Chofecalciferol rodenticides Sofanum malacoxykm Cestnim diumum Medial calcification of arteries... 

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