Mebendazole

Mebendazole (Vermox) blocks Hie uptake of glucose by the hekninth, resulting in a depletion of the hekninth s... 

Mebendazole is contraindicated in patients witii known hypersensitivity. Mebendazole is also contraindicated during pregnancy (Category C). The drug, like albendazole, has exhibited embryotoxic and teratogenic effects in experimental animals. Administration of mebendazole with tiie hydantoins and carbamazepine may reduce plasma levels of mebendazole. 

Mebendazole—The patient may chew, swallow whole, or mix the tablets with food. The patient should take these drugs with foods high in fat to increase absorption. The nurse should make sure a complete blood count is obtained before therapy and periodically during therapy because mebendazole can cause leukopenia or thrombocytopenia. 

The drug of choice for nematode infestations (hookworm, enterobiasis, and ascariasis) is mebendazole, while ivermectin is indicated for strongyloidiasis and praziquantel is indicated for tapeworms. 

In both adults and pediatric patients older than 2 years of age, mebendazole 100 mg twice daily for 3 days is the treatment to use. An alternative agent is pyrantel pamoate (Antiminth). The stool should be checked within 2 weeks and the patient retreated when warranted. 

Albendazole Bromoxanide Bunamidine Cambedazole Clioxanide Cyclobendazole Flubendazole Lobendazole Antihistaminics Mebendazole Niclosamide Nitramisole Nitrodan Oxantel Oxfendazole Oxibendazole Thenium Closylate... 

Yao, C., Bohnet, S. and Jasmer, D.P. (1998) Host nuclear abnormalities and depletion of nuclear antigens induced in Trichinella spiralis-miected muscle cells by the anthelmintic mebendazole. Molecular and Biochemical Parasitology 96, 1-13. 

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