Mebendazole, hypersensitivity reactions

Short-term mebendazole therapy for intestinal nematodes is nearly free of adverse effects. Mild nausea, vomiting, diarrhea, and abdominal pain have been reported infrequently. Rare side effects, usually with high-dose therapy, are hypersensitivity reactions (rash, urticaria), agranulocytosis, alopecia, and elevation of liver enzymes. 

More effective, less toxic compounds largely have replaced older ascaricides. Mebendazole, pyrantel pamoate (Antiminth, others), and albendazole are preferred agents. Piperazine also is effective but is used less often because of occasional neurotoxicity hypersensitivity reactions. Cure with any of these drugs is achieved in nearly 100% of cases, and all infected persons should be treated. Mebendazole and albendazole are preferred for therapy of asymptomatic to moderate ascariasis. Both of... 

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