Mebendazole teratogenic effects

Mebendazole is contraindicated in patients witii known hypersensitivity. Mebendazole is also contraindicated during pregnancy (Category C). The drug, like albendazole, has exhibited embryotoxic and teratogenic effects in experimental animals. Administration of mebendazole with tiie hydantoins and carbamazepine may reduce plasma levels of mebendazole. 

Depending on the species, parbendazole, mebendazole, albendazole, oxfendazole, cambendazole, and febantel can be teratogenic in the parent form or indirectly from metabolite formation. Oxibendazole and fenbendazole in parent form are not teratogenic, although one of the metabolites of fenbendazole, a sulfoxide found in the milk of cows treated with fenbendazole, is teratogenic in the rat and sheep. Albendazole displays similar biotransformation pathways in cattle as it does in sheep, yet the bovine animal is refractory to its teratogenic effect at normal dosage rates. 

Correct answer = D. Mebendazole is effective against nematodes, in part by decreasing glucose uptake, and thus causing the parasite to starve. Mebendazole has been shown to be embryotoxic and teratogenic in experimental animals v /... 

Mebendazole Effects on haematology and blood chemistry in 13 week oral dog study teratogenic effects in rats (2.5 mg/kg bw/day) 200 0.0125... 

Evidence of teratogenicity in rats has not been accompanied by reports that it causes harm in human pregnancy, but the WHO recommends avoidance during the first trimester. It is not known if mebendazole enters the breast milk no adverse effects have been reported but the issue has not been specifically studied. 

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