Mebendazole Phenytoin

Mebendazole is teratogenic in animals and therefore contraindicated in pregnancy. It should be used with caution in children younger than 2 years of age because of limited experience and rare reports of convulsions in this age group. Plasma levels may be decreased by concomitant use of carbamazepine or phenytoin and increased by cimetidine. Mebendazole should be used with caution in patients with cirrhosis. 

Mebendazole Accidental mebendazole poisoning in infants is associated with convulsions, respiratory arrest, and tachyarrhythmia.181 If administered concomitantly, mebendazole interacts with phenytoin, carbamazepine, and cimetidine. 

MEBENDAZOLE ANTIEPILEPTICS -CARBAMAZEPINE, PHENYTOIN 1 mebendazole levels Induction of metabolism Watch for poor response to mebendazole... 

Codeine Hydrochloride Dequalinium Acetate Fluorometholone Hexamethonium Bromide Riboflavine Stilbazium Iodide Mianserin Hydrochloride Tacrine Hydrochloride Diclofenac Sodium Vinblastine Sulphate Cyclizine Hydrochloride Amiloride Hydrochloride Protoveratrine B Meclofenamate Sodium 5-Methyltryptamine Hydrochloride Dicoumarol Mebendazole Pipradrol Hydrochloride Carbenoxolone Flucytosine Phanquone Phenytoin... 

Transporter efflux transporter effects predominant Examples Amiodarone Atorvastatin Azithromycin Carbamazepine Carvediioi Chlorpromazine Ciprofloxacin Cisapride Cyciosporine Danazoi Dapsone Diclofenac Diflunisal Digoxin Erythromycin Flurbiprofen Glipizide Glyburide Griseofulvin Ibuprofen Indinavir Indomethacin Itraconazole Ketoconazole Lansoprazole Lovastatin Mebendazole Naproxen Nelfinavir Ofloxacin Oxaprozin Phenazopyridine Phenytoin Piroxicam Raloxifene Ritonavir Saquinavir Saquinavir Sirolimus Sirolimus Spironolactone Spironolactone Tacrolimus Tacrolimus ... 

Mebendazole exerts its effects slowly (3 days), and effectiveness of treatment depends on the degree of infection or resistance of the parasites to treatment. Phenytoin or car-bamazepine reduce the plasma level of mebendazole. The major nematode parasites of humans include soil-transmitted helminths (STHs sometimes referred to as geohelminths ) and the filarial nematodes. 

Phenytoin, carbamazepine and phenobarbital lower the plasma levels of albendazole and mebendazole, and they therefore might reduce their efficacy for systemic infections. Valproate does not lower plasma mebendazole levels. 

A retrospective analysis found that patients with eehinoeoeeosis taking mebendazole and phenytoin or carbamazepine tended to have lower plasma mebendazole levels than patients not taking these antiepilepties. Valproic acid tended to increase mebendazole levels, and some patients had a clinically important rise in mebendazole levels when they were switched from phenytoin or carbamazepine to valproic acid. ... 

Phenytoin, carbamazepine and phenobarbital appear to induce the oxidative metabolism of albendazole by the cytochrome P450 isoenzyme CYP3A to roughly the same extent, resulting in significantly reduced levels of albendazole sulfoxide. Phenytoin, and to a lesser extent carbamazepine, may also induce the metabolism of albendazole sulfone by CYP2C. Mebendazole is similarly affected. 

These pharmacokinetic interactions are established, and are likely to be clinically important when these anthelmintics are used to treat systemic worm infections. For these infections it may be necessary to increase the albendazole or mebendazole dosage in patients taking phenytoin, carbamazepine or phenobarbital. Monitor the outcome of concurrent use. The interactions are of no importance when these anthelmintics are used for intestinal worm infections (where their action is a local effect on the worms in the gut), which is the most common use of mebendazole in particular. 

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