Mean cell hemoglobin

Mean cell hemoglobin (MCH) 27-33 pg/cell Amount of Hgb per RBC may be decreased in iron deficiency anemia. 

Mean cell hemoglobin concentration (MCHC) Iron Studies Serum iron 33.4-35.5 g/dL (334-355 g/L) Hemoglobin divided by the hematocrit also low in iron-deficiency anemia. 

G) reductions, - 10%, in hemoglobin and mean cell hemoglobin concentration anemia) ... 

Reductions of approximately 10% in total hemoglobin and mean cell hemoglobin were observed in rats receiving 1,000 mg/kg/day of MIL-H-83282LT for 4 weeks (Mattie et al. 1993). A 47% increase in white blood cell counts was also observed in this study. No effects on hematological parameters were seen in rats similarly exposed to MIL-H-83282 (Mattie et al. 1993). 

Polyalphaolefin Hydraulic Fluids. Studies examining hematological effects in humans or animals following inhalation, oral, or dermal exposure to polyalphaolefin hydraulic fluids are limited to a 4-week study in rats orally exposed to 1,000 mg/kg/day of MIL-H-83282 or MIL-H-83282LT (Mattie et al. 1993). No effect was seen with MIL-H-83282 but reductions in total and mean cell hemoglobin as well as anemia were seen in rats exposed to MIL-H-83282LT. 

MCV, mean cell volume MCHC, mean cell hemoglobin concentration SI, serum iron TIBC, transferrin iron-binding capacity. 

Gd gestational day (Gl) = gastric intubation (GO) = gavage in oil Hemato - hematological incr. = increased IPTPP = isopropyl triphenyl phosphate LD = lethal dose, 50% kill LOAEL = lowest-observed-adverse-effect level M = male MCV = mean corpuscular volume MCHC = mean corpuscular hemoglobin concentration mo = month(s) Musc/skel = musculoskeletal NOAEL = no-observed-adverse-effect level NS = not specified NTE = neurotoxic esterase RBC red blood cell Resp = respiratory TBEP = tributoxyethyl phosphate TBP = tributyl phosphate TMP = trimethyl phosphate TNBP = tri-n-butyl phosphate TOP = trioctyl phosphate wk = week(s) x = times yr = year(s). 

F, female M, male MCH, mean corpuscular hemoglobin MCHC, mean corpuscular hemoglobin concentration MCV, mean corpuscular volume RBC, red blood cell RDW, red blood cell distribution TIBC, total iron-binding capacity. 

LTso = time to 50% kill M = male MCH = mean corpuscular hemoglobin MCV = mean corpuscular volume min = minute(s) mo = month(s) Musc/skel = musculoskeletal NOAEL = no-observable-adverse-effect level NS = not specified RBC = red blood cell Resp = respiratory ... 

Rat (CD) 10-14 d 1 x/d (GO) Hemato 10 (increase in packed cell volume, erythrocytes, neutrophils decrease in mean corpuscular hemoglobin and platelet count) Weissberg and Zinkl 1973... 

Patients with this abnormality suffer from mild hypochromic anemia with microcytosis and signs of hemolysis a highly characteristic property is the 2- to 3-fold increase in the relative production of Hb-Aa. The Hb-level may vary between 7.5 and 11.5 g/100 ml. Anemia is the most common disturbance followed by hepatomegaly, gall stones, jaundice, splenomegaly, and others (G5). The red blood cell count varies between 5.5 and 7,5 million/mm with mean cell volumes (MCV) of 55-80 and mean cellular hemoglobin concentrations (MCHC) of 25-30%. The peripheral blood film shows hypochromia and microcytosis,... 

A 30-year-old woman had a hemoglobin concentration of 3.1 g/dl, a mean cell volume of 77 fl, a reticulocyte count of 2.13%, a platelet count of 426 x 10 /1, a serum iron concentration of 5 ng/ml, a transferrin saturation of 1%, and a ferritin concentration of 8 ng/ml. She was intolerant of oral iron and was given intramuscular iron dextran, 100 mg/day for 8 days, when she developed asymptomatic thrombocytopenia (platelet count 20 X 10 /1). Iron dextran was withdrawn and she took oral ferrous fumarate 200 mg/day plus ascorbic acid 120 mg/day. Within 2 days her platelet count improved. 

The classic example is monoclinic C2 horse hemoglobin studied by Max Perutz. In this crystal form it was known from density measurements that the C2 unit cell contained two entire molecules of hemoglobin. There are four asymmetric units in a C2 unit cell, however, as the International Tables show. Thus one-half of a hemoglobin, to satisfy space group symmetry, had to be related to the other half by a twofold axis. By this means horse hemoglobin was shown to possess a perfect twofold axis of symmetry well before it was demonstrated by any other means. 

---