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MDM2 oncogene

Wang, 2000b). Several recent reviews provide comprehensive discussion of MDM2 oncogene and its functions, as well as its interaction with various cellular proteins (Momand and Zambetti, 1997 Prives, 1998 Lozano and Montes de Oca Luna, 1998 Juven-Gershon and Oren, 1999 Freedman et al., 1999 Freedman and Levine, 1999). [Pg.40]

Landers, J.E., Cassel, S.L. and George, D.L. (1997) Translational enhancement of MDM2 oncogene expression in human tumor cells containing a stablized wild-type p53 protein. Cancer Res., 57, 3562-3568. [Pg.47]

Watanabe, T., Hotta, T., Ichikawa, A., Kinoshita, T., Nagai, H. and Uchida, T. (1994) The MDM2 oncogene overexpression in chronic lymphocytic leukemia and low-grade lymphoma of B-cell origin. Blood, 84, 3158-3165. [Pg.48]

Zhang, R. and Wang, H. (2000b) MDM2 oncogene as a novel target for human cancer therapy. Curr. Pharm. Design, 6, 393 116. [Pg.48]

Fakharzadeh SS, Rosenblum-Vos L, Murphy M et al (1993) Structure and organization of amplified DNA on double minutes containing the mdm2 oncogene. Genomics 15 283-290... [Pg.76]

Kratzer F, Rosorius O, Heger P, Hirschmann N, Dobner T, Hauber J, Stauber R (2000) The adenovirus type 5 E1B-55K oncoprotein is a highly active shuttle protein and shuttling is independent of E4orf6, p53 and Mdm2. Oncogene 17 850-857... [Pg.315]

Juven, T., et ah. Wild type p53 can mediate sequence-specific transactivation of an internal promoter within the mdm2 gene. Oncogene, 1993,... [Pg.96]

Honda, R. and H. Yasuda, Activity of MDM2, a ubiquitin ligase, toward p53 or itself is dependent on the RING finger domain of the ligase. Oncogene, 2000, 19(11), 1473-6. [Pg.97]

Midgley, C. a., et al., An N-terminal pl4ARF peptide blocks Mdm2-dependent ubiquitination in vitro and can activate p53 in vivo. Oncogene,... [Pg.98]

Ionov, Y, Nowak N, Perucho M, Markowitz S, Cowell JK (2004) Manipulation of nonsense mediated decay identifies gene mutations in colon cancer Cells with microsatellite instability. Oncogene 23 639-645 Ito A, Lai CH, Zhao X, Saito S, Hamilton MH, Appella E, Yao TP (2001) p300/CBP-mediated p53 acetylation is commonly induced by p53-activating agents and inhibited by MDM2. EMBO J 20 1331-1340... [Pg.256]

Figure 3. Oncogenic potential of ubiquitin ligases. MDM2 and Skp2 regulate levels of the tumor suppressors p53 and p27, respectively. Deregulated degradation of p53 and p27 results in cyclin E/cdk2 activation and cell proliferation. Figure 3. Oncogenic potential of ubiquitin ligases. MDM2 and Skp2 regulate levels of the tumor suppressors p53 and p27, respectively. Deregulated degradation of p53 and p27 results in cyclin E/cdk2 activation and cell proliferation.
Kondo S, Barnett GH, Kara H, Morimura T, Takeuchi J (1995a) MDM2 protein confers the resistance of a human glioblastoma cell line to cisplatin-induced apoptosis. Oncogene 10 2001-2006... [Pg.78]

Arriola, E.L., Lopez, A.R. and Chresta, C M. (1999) Differential regulation ofp21/waf-l/cip-1 andmdm2 by etoposide etoposide inhibits the p53-mdm2 autoregulatory feedback loop. Oncogene, 18,1081-1091. [Pg.46]

Midgley, C.A. and Lane, D.P. (1997) P53 protein stability in tumor cells is not determined by mutation but is dependent on MDM2 binding. Oncogene, 15, 1179-1189. [Pg.47]

Piette, J., Neel, H. andMarechal, V. (1997) MDM2 keeping p53 under control. Oncogene, 15, 1001-1010. [Pg.48]

Wasylyk C, Salvi R, Argentini M, Dureuil C, Delumeau I, Abecas-sis J, Debussche F, Wasylyk B. p53 mediated death of cells overexpressing MDM2 by an inhibitor of MDM2 interaction with p53. Oncogene 1999 18 1921-1934. [Pg.1587]

The pathways that mediate genotoxic, non-genotoxic and oncogenic stress are the target of a multitude of selection pressures, and these pressures will converge on the p53-MDM2 module, acting either separately or in combination. [Pg.507]

Picksley SM, Vojtesek B, Sparks A, Lane DP (1994) Immunochemical analysis of the interaction of p53 with MDM2-fine mapping of the MDM2 binding site on p53 using synthetic peptides. Oncogene 9 2523-2529... [Pg.49]

Capoulade C, Bressac-de Paillerets B, Lefrere I et al (1998) Overexpression of MDM2, due to enhanced translation, results in inactivation of wild-type p53 in Burkitt s lymphoma cells. Oncogene 16 1603-1610... [Pg.76]

Bottger V, Bottger A, Garcia-Echeverria C et al (1999) Comparative study of the p53-mdm2 and p53-MDMX interfaces. Oncogene 18 189-199... [Pg.78]

E. Brambilla, Mdm2 overexpression and pl4ARF inactivation are two mutually exclusive events in primary human lung tumors, Oncogene 2002, 21, 2750-2761. [Pg.1000]


See other pages where MDM2 oncogene is mentioned: [Pg.378]    [Pg.392]    [Pg.40]    [Pg.44]    [Pg.48]    [Pg.375]    [Pg.378]    [Pg.392]    [Pg.40]    [Pg.44]    [Pg.48]    [Pg.375]    [Pg.331]    [Pg.62]    [Pg.77]    [Pg.24]    [Pg.290]    [Pg.314]    [Pg.155]    [Pg.60]    [Pg.39]    [Pg.290]    [Pg.575]    [Pg.581]    [Pg.582]    [Pg.582]    [Pg.154]    [Pg.1858]    [Pg.193]    [Pg.110]    [Pg.504]    [Pg.505]   
See also in sourсe #XX -- [ Pg.378 ]




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