Matrix assisted laser desorption/ionisation - time of flight

Saenz, A. J. Petersen, C. E. Valentine, N. Gantt, S. L. Karman, K. H. Kingsley, M. T. Wahl, K. L. Reproducibility of matrix-assisted laser desorption/ionisation time-of-flight mass spectrometry for replicate bacterial culture analysis. Rapid Comm. Mass Spectrom. 1999,13,1585-1585. 

Bright, J. J. Claydon, M. A. Soufian, M. Gordon, D. B. Rapid typing of bacteria using matrix-assisted laser desorption ionisation time-of-flight mass spectrometry and pattern recognition software. J. Microbiol. Meth. 2002, 48,127-138. 

Domin, M. A. Welham, K. J. Ashton, D. S. The effect of solvent and matrix combinations on the analysis of bacteria by matrix-assisted laser desorption/ ionisation time-of-flight mass spectrometry. Rapid Comm. Mass Spectrom. 1999, 13, 222-226. 

S.T. Hsiao, M.C. Tseng, Y.R. Chen and G.R. Her, Analysis of polymer additives by matrix-assisted laser desorption ionisation/time of flight mass spectrometer using delayed extraction and collision induced dissociation, J. Chinese Chem. Soc., 48 (2001) 1017-1027. 

Ferret, C., Pezet, R., and Tabacchi, R., Fractionation of grape tannins and analysis by matrix-assisted laser desorption/ionisation time-of-flight mass spectrometry, Phytochem. Anal, 14, 202,... 

Fig. 4.5.8 Examples for structures and molecular masses of 2-aminobenzamide (2-AB)-labelled oligosaccharide moieties derived from serum transferrin. Values below the oligosaccharide structures indicate the expected masses (in Da) by matrix-assisted laser desorption ionisation - time of flight analysis.

MALDI-TOF matrix-assisted laser desorption/ionisation time-of-flight... 

The mass spectrometry analysis was performed by the matrix assisted laser desorption/ionisation time-of-flight (S8-MALDI) technique using a Voyager-DE PRO Biospectrometry Workstation (Applied Biosystems, USA). Radiation pulses of 0.5 ns and 3 Hz frequency from N2 laser operating at 337 nm were used to desorb the species and negative/positive ions formed were detected in reflectron mode. Sulfur used as a matrix material was also dissolved in toluene and mixed with the samples solution prior to deposition onto a target. 

Rouse, J.C., Yu, W. and Martin, S.A. (1996) A comparison of the peptide fragmentation obtained from a reflector matrix-assisted laser desorption-ionisation time-of-flight mass and a tandem 4-sector mass spectrometer. J. Am. Mass Spectrom., 6 (9), 822-35. 

Weiss, K.C., Yip, T.T., Hutchens, T.W. and Bisson, L.F. (1998) Rapid and sensitive fingerprinting of wine proteins by matrix-assisted laser desorption/ionisation time-of-flight (MALDI-TOF) mass spectrometry, Am. J. Enol. Vitic., 49(3), 231-239. 

Bright, J.J. Claydon, M.A. Soufian, M. Gordon, D.B. "Rapid Typing of Bacteria Using Matrix-assisted Laser Desorption Ionisation Time-of-flight Mass Spectrometry and Pattern Recognition Software, J. Microbiol. Methods 48(2-3), 127-138 (2002). 

The mass spectrometry of oligonucleotides is a rapidly expanding research area dominated by the techniques of electrospray ionisation and matrix assisted laser desorption-ionisation, time of flight (MALDI-TOF) mass spectrometry. A number of reviews of this area have been published this year. Several... 

Matrix-assisted laser desorption ionisation/time of flight (i.e., MALD-TOF) MS Electrospray ionization MS SSCP - Quantitative single-strand conformation polymorphism analysis... 

A reliable analysis of multicomponent mixtures is particularly difficult and the situation becomes more complicated and less meaningful with increasing mixture size. Nevertheless, the analysis of peptide libraries is possible by mass spectroscopic means.366-572 mixture size increases, the main aim of any analysis is to ensure that the vast majority of expected library members are represented in the mixture. The use of MS in conjunction with other analytical techniques (HPLC-MS, GC-MS, MS-MS) have been used successfully in library characterisation. 3.425.573 Electronspray-MS is a particularly mild method for ionisation. s Matrix-assisted Laser Desorption Ionisation - time-of-flight (MALDI-TOF) mass spectrometry is a tool of increasing importance in multicomponent analysis. Its reduced tendency to preferential ionisation results in an increased likelihood of observing ions from all components.5 575... 

Chromatographic methods, such as reverse phase HPLC (RP-HPLC) and size exclusion chromatography, were used for identity and purity control, and also for quantitative measurement. The major impurity, which can be detected by RP-HPLC after the two first purification steps (Fig. 3), was isolated and analysed by mass spectrometiy. The mass measured by Matrix Assisted Laser Desorption Ionisation Time Of Flight (MALDI-TOF) mass spectrometry for this impurity was around twice the mass of the monomer (78265 Da), and was interpreted to be a dimer of BBG2Na. 

Matrix Assisted Laser Desorption Ionisation - Time Of Flight Mass Spectrometry (MALDI-TOF/MS)... 

D. Momcilovic, B. Wittgren, K. -G. Wahlund, J. Karlsson, and G. Brinkmalm, Sample preparation effects in matrix-assisted laser desorption/ionisation time-of-flight mass spectrometry of partially depolymerized carboxymethyl cellulose, Rapid. Commun. Mass. Spectrom., 17 (2003) 1107-1115. 

Mn value was observed as 3 kDa by matrix assisted laser desorption ionisation-time-of-flight mass spectrometer and synthetic pathways for (a-f) and (a ) are shown in Figure 9.1. Reproduced with permission from T. Eren, A. Som, J.R. Rennie, C.F. Nelson, Y. Urgina,... 

The polymers were characterised by NMR and matrix assisted laser desorption/ ionisation-time of flight MS (MALDI-TOF MS) [92]. They have variable indices of refraction (from 1.45-1.52), Tg from 265-350 °C, and long-term thermal stability at 623 K. The dependence of refractive index on wavelength were also measured and the constants of copolymerisation reaction were determined [92]. End-group analysis has been a reliable asset in PFCB chemistry and in particular for copolymerisation studies [92]. 

Matrix assisted laser desorption ionisation - time of flight mass spectrometry... 

Onnerfjord, P, Ekstrom, S., Bergquist, J., Nilsson, J., Laurell, T, and Marko-Varga, G, Homogeneous sample preparation for automated high throughput analysis with matrix-assisted laser desorption/ionisation time-of-flight mass spectrometry, Rapid Communications in Mass Spectrometry, 13,315-322, 1999. 

Carroccio, S., Rizzarelli, P, and Puglisi, C., Matrix-assisted Laser Desorption/ Ionisation Time-of-flight Characterisation of Biodegradable Aliphatic Cojxrlyes-ters. Rapid Comm. Mass Spectrom., 14, 1513, 2000. 

Maloney, D., Hunt, K. H., Lloyd, P. M., Muir, A. V. G., Richards, S. N., Derrick, P. J., and Haddleton, D. M., Polymethylmethacrylate End-group Analysis by Matrix-assisted Laser Desorption Ionisation Time-of-flight Mass Spectrometry (MALDl-TOF-MS), /. Chem. Soc., Chem. Commun., 5, 561, 1995. 

Blais, J. C., Tessier, M., Bolbach, G., Remaud, B., Rozes, L., Guittard, J., Brunot, A., Marechal, E., and Tabet, J. C., Matrix-assisted Laser Desorption Ionisation Time-of-flight Mass Spectrometry of S5mthetic Polyesters, Int. J. Mass Spectrom. Ion Processes, 144, 131, 1995. 

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