Mass spectrometry imaging lipids

Meriaux C, Franck J, Wisztorski M, Salzet M, Fournier I (2010) Liquid ionic matrixes for MALDI mass spectrometry imaging of lipids. J Proteomics 73 1204-1218. doi 10.1016/j. jprot.2010.02.010... 

Girod M, Shi Y, Cheng J, Cooks G (2010) Desorption electrospray ionization imaging mass spectrometry of lipids in rat spinal cord. J Am Soc Mass Spectrom 21 1177-1189. doi 10.1016/j. jasms.2010.03.028... 

Thomas, A., Charbonneau, J.L, Foumaise, E., and Chaurand, P. (2012) Sublimation of new matrix candidates for high spatial resolution imaging mass spectrometry of lipids enhanced information in both positive and negative polarities after l,5-diaminonapthalene deposition. Anal. Chem., 84, 2048-2054. 

Eberlin, L.S., Liu, X., Ferreira, C.R., Santagata, S., Agar, N.Y., and Cooks, R.G. 2011, Desorption electrospray ionization then MALDI mass spectrometry imaging of lipid and protein distributions in single tissue sections, Anal. Chem., 15 8366-8371. 

Mass spectrometry imaging with time-of-flight secondary ion mass spectrometry (ToF-SIMS) has revealed the spatial distribution of chemicals on a surface (1). When applied to biological samples, this method offers spatial information on biologically relevant small molecules (<1,000 Da). Indeed, ToF-SIMS imaging has been shown to be a powerful analytical tool for mapping the distribution of lipids on a cell membrane at the single-cell... 

Murphy, R.C., Hankin, J.A. and Barkley, R.M. (2009) Imaging of lipid species by MALDI mass spectrometry. J. Lipid Res. 50 Suppl, S317-S322. 

Trim, P. J. Atkinson, S. J. Princivalle, A. P Marshall, P. S. West, A. Clench, M. R., Matrix-assisted laser desorption/ionisation mass spectrometry imaging of lipids in rat brain tissue with integrated unsupervised and supervised multivariant statistical analysis , Rapid Commun. Mass Spectrom. 2008, 22, 1503-1509. 

Vidova, V. Novak, R Strohalm, M. Pol, J. Havlicek, V. Volny, M. Laser Desorption-Ionization of Lipid Transfers Tissue Mass Spectrometry Imaging Without MALDI Matrix. Anal. Chem. 2010,82,4994-4997. 

Sjovall, P., Lausmaa, J., Nygren, H., Carlsson, L., and Malmberg, P. (2003). Imaging of membrane lipids in single cells by imprint-imaging time-of-flight secondary ion mass spectrometry. Anal. Chem. 75 3429-3434. 

Veloso A, Astigarraga E, Barreda-Gomez G, Manuel I, Ferrer I, Giralt M, Ochoa B, Fresnedo O, Rodriguez-Puertas R, Fernandez J (2011) Anatomical distribution of lipids in human brain cortex by imaging mass spectrometry. J Am Soc Mass Spectrom 22 329-338. doi 10.1007/ s 13361-010-0024-5... 

Ellis S, Wu C, Deeley J, ZhuX, Truscott R, Panhuis J, Cooks R, Mitchell T, Blanksby S (2010) Imaging of human lens lipids by desorption electrospray ionization mass spectrometry. J Am Soc Mass Spectrom 21 2095-2104. doi 10.1016/j.jasms.2010.09.003... 

Nemes P, Woods A, Vertes A (2010) Simultaneous imaging of small metabolites and lipids in rat brain tissue at atmospheric pressure by laser ablation electrospray ionization mass spectrometry. Anal Chem 82 982-988. doi 10.1021/ac902245p... 

Although information on the spatial distribution of membrane lipids can be important (3), most mass-spectrometric approaches used in lipidomics focus currently on the determination of total lipid composition. An advanced mass-spectrometric surface analysis technique, however, secondary ion mass spectrometry (SIMS) determines lipid compositions within different areas of freeze-fractured cells (12). This technique and related imaging techniques will become important tools in lipidomics. 

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