Desorption electrospray ionization imaging

Girod M, Shi Y, Cheng J, Cooks G (2010) Desorption electrospray ionization imaging mass spectrometry of lipids in rat spinal cord. J Am Soc Mass Spectrom 21 1177-1189. doi 10.1016/j. jasms.2010.03.028... 

Watrous J, Hendricks N, Meehan M, Dorrestein P (2010) Capturing bacterial metabolic exchange using thin film desorption electrospray ionization-imaging mass spectrometry. Anal Chem 82 1598-1600. doi 10/1021/ac9027388... 

Watrous J, Roach P, Heath B, Alexandrov T, Laskin J, Dorrestein PC. Metabolic profiling directly from the petri dish using nanospray desorption electrospray ionization imaging mass spectrometry. Anal Chem. 2013 85 10835-391. 

Dill, A.L., Ifa, D.R., Manicke, N.E., Costa, A.B., Ramos-Vara, J.A., Knapp, D.W. and Cooks, R.G. (2009) Lipid profiles of canine invasive transitional cell carcinoma of the urinary bladder and adj acent normal tissue by desorption electrospray ionization imaging mass spectrometry. Anal. Chem. 81, 8758-8764. 

Masterson, T.A., Dill, A.L., Eberlin, L.S., Mattarozzi, M., Cheng, L., Beck, S.D., Bianchi, F. and Cooks, R.G. (2011) Distinctive glycerophospholipid profiles of human seminoma and adjacent normal tissues by desorption electrospray ionization imaging mass spectrometry. J. Am. Soc. Mass Spectrom. 22,1326-1333. 

J. M. Wiseman, D. R. Ifa, Q. Song and R. G. Cooks, Tissue imaging at atmospheric pressure using Desorption Electrospray Ionization (DESI) mass spectrometry, Angew. Chem. Int. Edn, 45, 7188 7192 (2006). 

Kertesz, V., and Van Berkel, G. J. (2008). Improved imaging resolution in desorption electrospray ionization mass spectrometry. Rapid Commun. Mass Spectrom. 22 2639-2644. 

Dill A, Ifa D, Manicke N, Zheng O, Cooks R (2009) Mass spectrometric imaging of lipids using desorption electrospray ionization. J Chromatogr B 877 2883-2889. doi 10.1016/j. jchromb.2008.12.058... 

Ellis S, Wu C, Deeley J, ZhuX, Truscott R, Panhuis J, Cooks R, Mitchell T, Blanksby S (2010) Imaging of human lens lipids by desorption electrospray ionization mass spectrometry. J Am Soc Mass Spectrom 21 2095-2104. doi 10.1016/j.jasms.2010.09.003... 

Ifa D, Wiseman J, Song Q, Cooks G (2007) Development of capabilities for imaging mass spectrometry under ambient conditions with desorption electrospray ionization (DESI). Int J Mass Spectrom 259 8-15. doi 10.106/j.ijms.2006.08.003... 

Kertesz V, van Berkel G, Vavrek M, Koeplinger K, Schneider B, Covey T (2008) Comparison of drug distribution images from whole-body thin tissue sections obtained using desorption electrospray ionization tandem mass spectrometry and autoradiography. Anal Chem 80 5168-5177. doi 10.1021/ac800546a... 

Manicke N, Dill A, Ifa D, Cooks R (2010) High-resolution tissue imaging on an orbitrap mass spectrometry by desorption electrospray ionization mass spectrometry. J Mass Spectrom 45 223-226. doi 10.1002/jms,1707... 

Wiseman J, Ifa D, Zhu Y, Kissinger C, Manicke N, Kissinger P, Cooks R (2008) Desorption electrospray ionization mass spectrometry imaging drug and metabolites in tissues. Proc Natl Acad Sci USA 105(47) 18120-18125. doi 10.1073/pnas.0801066105... 

Wiseman, J.M. et al., Ambient molecular imaging by desorption electrospray ionization mass spectrometry, Nat. Protocols, 3(3), 517, 2008. 

Today, M S imaging is perceived as a rather new - but very promising - approach, not only for the basic sciences but also for clinical diagnosis [156]. Although other MS imaging methods based on desorption electrospray-ionization (DESI) MS [157] or secondaryion mas s spectrometry (SIMS)are currently available (for a timely review, see Ref. [158]), attention here will be focused exclusively on MALDI-MS imaging. The same technique is also discussed comprehensively in Chapter 4 of this book. 

Van Berkel, G.J., Kertesz, V. (2006) Automated sampling and imaging of analytes separated on thin-layer chromatography plates using desorption electrospray ionization mass spectrometry. Analytical Chemistry, 78,4938-4944. 

In Chapter 4, titled Principles of Mass Spectrometry Imaging Applicable to Thin-Layer Chromatography, the authors first introduce a budding analytical approach known as imaging mass spectrometry (IMS) strategy and then present some successful examples of its practical applications. Then, they introduce in detail three mass spectrometric techniques as those routinely used within the framework of IMS. These are secondary mass spectrometry (SIMS), matrix-assisted laser desorption/ ionization (MALDI-IMS), and desorption electrospray ionization (DESI). Finally, the authors discuss the advances and bottlenecks of these techniques when applied to TLC. 

Currently, there are at least three ionization techniques routinely used in IMS (1) secondary ion mass spectrometry (SIMS), (2) matrix-assisted laser desorption ionization (MALDI), and (3) desorption electrospray ionization (DESI). Each of these ion sources has their own advantages and drawbacks thus, they are usually selected in the context of the imaged sample. In the following text, we provide a concise description of these devices. 

Eberlin, L.S., Liu, X., Ferreira, C.R., Santagata, S., Agar, N.Y., and Cooks, R.G. 2011, Desorption electrospray ionization then MALDI mass spectrometry imaging of lipid and protein distributions in single tissue sections, Anal. Chem., 15 8366-8371. 

Laskin, J., Heath, B.S., Roach, P.J., Cazares, L., and Semmes, O.J. 2012, Tissue imaging using nanospray desorption electrospray ionization mass spectrometry. Anal. Chem., 84 141-148. 

Key words Imaging mass spectrometry, secondary ion mass spectrometry, matrix-assisted laser desorption ionization, desorption electrospray ionization, brain. 

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