Mapping, receptor functional

These findings were unexpected because previous studies had demonstrated that the y2 subunit is required for potentiation of GABAa receptor function by low concentrations of ethanol [2]. The y2 subunit gene is located within a definitely mapped quantitative trait locus (QTL) for acute alcohol withdrawal on mouse chromosome 11 [1]. Allelic variation was genetically... 

Geva, A., Lassere, T. B., Lichtarge, O., Pollitt, S. K., and Baranski, T. J. (2000) Genetic mapping of the human C5a receptor. Identification of transmembrane amino acids critical for receptor function. J. Biol. Chem. 275, 35393-35401. 

Hope, T.J., Huang, X.J., McDonald, D. and Parslow, T.G. (1990) Steroid-receptor fusion of the human immunodeficiency virus type 1 Rev transactivator mapping cryptic functions of the arginine-rich motif. Proc. Nad. Acad. Sci. USA, 87, 7787-7791. 

Sher, T., Yt H. F McBride, O. W., and Gonzalez, F. J. (1993). cDNA Cloning, Chromosomal Mapping, and Functional Characterization of the Human Peroxisome Proliferator Activated Receptor. Biochemistry 32, 5598-5604. 

Sher T, Yi HF, McBride OW, Gonzalez FJ. cDNA cloning, chromosomal mapping, and functional characterization of the human peroxisome proliferator activated receptor. Biochemistry 1993 32 5598-604. 

McCormack, D. G., Mak, J. C. W., Coupe, M. O., and Barnes, P. J. (1989). Calcitonin gene-related peptide vasodilation of human pulmonary vessels receptor mapping and functional studies. J. Appl. Physiol. 67, 1265-1270. 

Neurotrophins (NGF brain-derived neurotrophic factor, BDNF neurotrophin-3, NT-3 NT-4 NT-6) are important regulators of neural survival, development, function, and plasticity of the vertebrate nervous system [1]. Neurotrophins generally function as noncovalently associated homodimers. They activate two different classes of receptors, through which signaling pathways can be activated, including those mediated by Ras and members of the cdc42/rac/rho G protein families, MAP kinase, PI-3 kinase, and Jun kinase cascades. 

Damaj BB, McColl SR, Neote K, et al. Identification of G-protein binding sites of the human interleukin-8 receptors by functional mapping of the intracellular loops. FASEB J 1996 10(12) 1426-1434. 

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