Mapping, receptor

The essential feature of the AAA is a comparison of active and inactive molecules. A commonly accepted hypothesis to explain the lack of activity of inactive molecules that possess the pharmacophoric conformation is that their molecular volume, when presenting the pharmacophore, exceeds the receptor excluded volume. This additional volume apparently is filled by the receptor and is unavailable for ligand binding this volume is termed the receptor essential volume [3]. Following this approach, the density maps for each of the inactive compounds (in their pharm conformations superimposed with that of active compounds) were constructed the difference between the combined inactive compound density maps and the receptor excluded volume represents the receptor essential volume. These receptor-mapping techniques supplied detailed topographical data that allowed a steric model of the D[ receptor site to be proposed. 

DM Mottola, S Laiter, VJ Watts, A Tropsha, SW Wyrick, DE Nichols, P Mailman. Conformational analysis of d dopamine receptor agonists Pharmacophore assessment and receptor mapping. J Med Chem 39 285-296, 1996. 

Human glucocorticoid receptor maps to the long aim of chromosome 5 (5q31-5q32) whereas human mineralocorticoid receptor maps to the long arm of chromosome 4 (4q31.1). 

P.J. Lewi and H. Moereels, Receptor mapping and phylogenetic clustering. In Advanced Computer-Assisted techniques in Drug Discovery (H. van de Waterbeemd, Ed.). VCH, Weinheim, Germany, 1994, pp. 131-162. 

Chabot, B., Stephenson, D. A., Chapman, V. M., Besmer, P., and Bernstein, A. (1988). The proto-oncogene c-kit encoding a transmembrane tyrosine kinase receptor maps to the mouse W locus. Nature 335 88-89. 

Agonist-induced conformational changes at the cytoplasmic side of TM6 in the beta 2 adrenergic receptor mapped by site-selective fluorescent labeling. J. Biol. Chem. 276,9279-9290. 

Kuhar MJ, De Souza EB, Unnerstall JR. 1986. Neurotransmitter receptor mapping by autoradiography and other methods. Annu Rev Neurosci 9 27-59. 

Computer-Assisted Drug Receptor Mapping Analysis... 

KARMA is an interactive computer assisted drug design tool that incorporates quantitative structure-activity relationships (QSAR), conformational analysis, and three-dimensional graphics. It represents a novel approach to receptor mapping analysis when the x-ray structure of the receptor site is not known, karma utilizes real time interactive three-dimensional color computer graphics combined with numerical computations and symbolic manipulation techniques from the field of artificial intelligence. 

The above examples used to illustrate the specific rules for backward chaining are similar to other attempts at receptor mapping. ) However, these other methods do not account for interactions that may be based on a combination of effects such as hydrophobicity and ligand potency. For instance, a rule that might apply to a compound with a substituted phenyl ring may take the form( ... 

Talele, T. T. and Kulkami, V. M. (1999) Three-dimensional quantitative structure-activity relationship (QSAR) and receptor mapping of cytochrome P-450(14 alpha DM) inhibiting azole antifungal agents.. /. Chem. Inf. Comput. Sci. 39, 204-210. 

D. C. Rohrer, D. S. Fullerton, K. Yoshioka, A. H. L. Frome, K. Ahmed (1979). Functional receptor mapping for modified cardenolides use of the Prophet system. In E. C. Olson, R. E. Christoffersen (Eds.). Computer Assisted Drug Design. Washington, DC American Chemical Society, pp. 259-279. 

Jensen, A. D., Guarnieri, F., Rasmussen, S. G., Asmar, F., Ballesteros, J. A., and Gether, U. (2001). Agonist-induced conformational changes at the cytoplasmic side of transmembrane 6 in the beta 2 adrenergic receptor mapped by site-selective fluorescent labeling./. Biol. Chem. 276, 9279-9290. 

Fast Drug-Receptor Mapping by Site-Directed Distances A Novel Method of Predicting New Pharmacological Leads. 

The tonB mutation, which had already been connected to iron transport (see above), also affected the outer membrane. Inspection of the region of the E. coli linkage map analogous to the sid locus in S. typhimurium revealed that tonA, the structural gene for the T5 outer membrane receptor, maps near pan. These considerations raised the possibility that the tonA product could be related to ferrichrome and a sid function in E. coli. The characteristics of the ton mutations known at that time, with the exception of albomycin resistance, are recorded in Table I. 

Indolealkylamines, [ Cj-dimethyltryptamine (UC-DMT, 304), [nC]-5-methoxy-A,iV-dimethyltryptamine ([uC]-5-OMe DMT, 305) and [nC]-bufetenine 306, known to have hallucigenic properties285 and expected to serve as potential serotonin-1 receptor mapping radiopharmaceuticals, have been synthesized286 (equation 119) in 46%, 18% and 8.9% overall radiochemical yields, respectively, with average specific activity of 63 Ci mmol"1 at the time of use. 

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