Functional mapping

Damaj BB, McColl SR, Neote K, et al. Identification of G-protein binding sites of the human interleukin-8 receptors by functional mapping of the intracellular loops. FASEB J 1996 10(12) 1426-1434. 

Miranker A, Karplus M. Functionality maps of binding sites a multiple copy simultaneous search method. Proteins 1991 11 29-34. 

The purposes of this paper are to discuss the CO effect on the i (r)-function and to show that the appearance of the atom-like image can be explained by using the fact that the 5(r)-function can be described in terms of the autocorrelation function among the electron wave functions over the occupied electronic states. Autocorrelative overlap between the CO terms explicitly containing the atomic information has a possibility to enhance a specific atom on the i (r)-function map. The overlap explains why images of the other distant atoms are not pronounced. 

Vidal, M. (2001). A biological atlas of functional maps. Cell 104, 333-339. 

McQuade Sharp (1997) tested whether electrical stimulation of the DRN or the MRN releases 5-HT in rat forebrain regions in a pattern that correlates with the distribution of 5-HT projections from the serotonergic nuclei. Stimulation of the DRN evoked the release of 5-HT in the frontal cortex, dorsal striatum, globus pallidus, and ventral hippocampus. Conversely, 5-HT release in dialysates collected from the dorsal and ventral hippocampus and the medial septum was increased in response to MRN stimulation. Thus, the functional mapping of DRN... 

McQuade, R. Sharp, T. (1997). Functional mapping of dorsal and median raphe 5-hydroxytryptamine pathways in forebrain of the rat using microdialysis. 

Horinouchi, S. and Weisblum, B. (1982) Nucleotide sequence and functional map of pE194, a plasmid that specifies inducible resistance to macrolide, lincosamide, and streptogramin type B antibodies. Journal of... 

One of the most significant applications of STM to electrochemistry would involve the application of the full spectroscopic and imaging powers of the STM for electrode surfaces in contact with electrolytes. Such operation should enable the electrochemist to access, for the first time, a host of analytical techniques in a relatively simple and straightforward manner. It seems reasonable to expect at this time that atomic resolution images, I-V spectra, and work function maps should all be obtainable in aqueous and nonaqueous electrochemical environments. Moreover, the evolution of such information as a function of time will yield new knowledge about key electrochemical processes. The current state of STM applications to electrochemistry is discussed below. 

E. Watanabe, Y. Yamashita, A. Maki, Y. Ito, and H. Koizumi. Noninvasive functional mapping with multi-channel near infrared spectroscopic topography in humans. Neuroscience Letters, 205 41-44, 1996. 

Critical periods are those in which the synaptic circuitry of a given brain region becomes stabilized in a functionally optimized conformation. The cerebral cortex and other brain structures contain functional maps for the activities characteristic of a species. The best example is the ocular dominance columns and other physical and functional characteristics of the circuitry within the visual cortical system that process information derived from the left and right visual fields, producing a map of the visual world. Other internal maps exist for the body (somatosensory, motor corti-... 

The design function rests upon recognition and implementation of the relationships shown in Figure 1. In part A we formalize that not only do all BRs map into (depend upon) CS, but so do all physicochemical properties, PPs. Therefore, the CS can, from functional mapping, be considered the common node between the BRs and the PPs. Consequently, a unique function, f, must exist between each BR and the set of PP. This is defined in part B of Figure 1. 

A functional map of the Na+ channel a subunits. The transmembrane folding model of the a subunit is depicted with experimentally demonstrated sites of cAMP-dependent phosphorylation (P), interaction of site-directed antibodies that define transmembrane orientation covalent attachment... 

Fig.4 Individual Potential Source Contribution Function maps for toxaphene (A) Michigan (B) Indiana (C) Arkansas (D) Louisiana from Hoh and Hites [45]. Dark red represents PSCF values from 0.91 to 1.0, with shades of pink ranging down to 0.61 by tenths, and white represents from 0.41 to 0.60. Dark blue represents 0-0.10, with shades of blue ranging up to 0.40 by tenths. The green star in each map represents the sampling site. [Reproduced with permission from ACS]...

Johnson B. A., Ho S. L., Xu Z., Yihan J. S., Yip S., Hingco E.E. and Leon M. (2002) Functional mapping of the rat olfactory bulb using diverse odorants reveals modular responses to functional groups and hydrocarbon structural features. J. Comp. Neurol. 449(2), 180-194. 

Belliveau JW, Kennedy DN Jr, McKinstry RC, Buchbinder BR, Weisskoff RM, Cohen MS, Vevea JM, Brady TJ, Rosen BR (1991) Functional mapping of the human visual cortex by magnetic resonance imaging. Science 254 716-719... 

BH4 responsiveness has led Dr. Blau to create a functional database for the PAH molecule in which individuals can contribute to the functional mapping of genetic mutations (http // www.bh4.org). 

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