Manganese dietary calcium

Greger, J. L., Smith, S. A., and Snedeker, S. M. (1981). Effect of dietary calcium and phosphorus levels on the utilization of calcium, phosphorus, magnesium, manganese, and selenium by adult males. Nutr. Res. 1, 315-325. 

Calcium has long been implicated as a dietary factor which inhibits the absorption of manganese. Since manganese is better absorbed in the oxidized (+2) than in the reduced state (+3 or +4), any factor which increases gastrointestinal tract pH (increases alkalinity) would be expected to inhibit manganese utilization. Calcium carbonate, a commonly used antacid by humans as well as a calcium nutrient supplement, has been found to have a greater adverse effect on apparent manganese absorption in humans than does milk. 

Hsu FS, Krook L, Pond WG, Duncan JR (1975) Interaction of dietary calcium with toxic levels of lead and zinc in pigs. J. Nutr. 105 112-118 Jacobs, RM, Fox MRS, Jones AOL, Hamilton RP, Lener J (1977) Cadmium metabolism Individual effects of zinc, copper, and manganese. Fed. Proc. 36 1152 Johnson NE, Tenuta K (1979) Diets and lead blood levels of children who practice pica. Environ. Res. 18 369-376... 

What do the ions of the following elements have in common calcium, Ca chlorine. Cl chromium, Cr cobalt, Co copper, Cu fluorine, F iodine, I iron, Fe magnesium. Mg manganese, Mn molybdenum, Mo nickel, Ni phosphorus, P potassium. K selenium, Se sodium, Na sulfur, S zinc, Zn They are all dietary minerals essential for good health, but can be harmful, even lethal, when consumed in excessive amounts. 

Our interest in the role of trace elements in bone metabolism developed in a rather bizarre fashion. Ve became interested in the orthopedic problems of a prominent professional basketball player. Bill Walton. Several years ago he was plagued by frequent broken bones, pains in his joints and an inability to heal bone fractures. We hypothesized that he might be deficient in trace elements as a result of his very limited vegetarian diet. In cooperation with his physician, we were able to analyze Walton s serum. We found no detectable manganese (Mn). His serum concentrations of copper (Cu) and zinc (Zn) were below normal values. Dietary supplementation with trace elements and calcium (Ca) was begun. Over a period of several months his bones healed and he returned to professional basketball (1,2). In cooperation with several other orthopedic physicians, we analyzed serum from other patients with slow bone healing. Several of these patients also had abnormally low Zn, Cu and Mn levels. 

A number of factors that may influence human requirements of manganese have been investigated in the literature. These factors include the iron status and age of the individual and dietary factors such as iron, calcium, phosphorus, phytates and fiber. 

Two human studies have reported increased, but not significant, losses of fecal manganese in subjects when dietary levels of phosphorus were increased from 800 to 1,500 mg (30) and from 1,010 to 2,525 mg/day (31). In animals, elevated dietary levels of phosphorus have been reported to increase manganese requirements (51) however, the dietary level of calcium in this study was also high. 

Cellulose. Fiber components differ in their ability to bind to bile (41), the primary route of excretion of manganese (9). Cellulose, the most abundant natural fiber, has been studied for its potential effects on bile and lipid metabolism (42). It is naturally present in high fiber diets and is also commonly added to many commercially-produced food products. Previous studies have shown cellulose to decrease intestinal uptake of a variety of minerals, including zinc, phosphorus, calcium, magnesium, and iron (32,43,44). In many cases, however, the effect of cellulose has not been considered to be anti-nutritional (32). It has been generally believed that cellulose has a lower binding affinity for minerals than other constituents of dietary fiber (33,45). 

Treatment of tardive dyskinesia is often unsatisfactory, especially in severe cases. A large number of treatments have been proposed (SEDA-20,40), including antiparkinsonian drugs, benzodiazepines, baclofen, hormones, calcium channel blockers, valproate, propranolol, opiates, cyproheptadine, tryptophan, lithium, manganese, niacin, botulinum toxin, ECT, dietary control, and biofeedback training. In an open study, 20 patients (mean age 65 years) with severe unresponsive tardive dyskinesia (mean duration 44 months, mean exposure 52 months) were treated with tetrabenazine (mean dose 58 mg/day) (310). The mean score on the AIMS motor subset, determined from videotapes, improved by 54%. Sedation was the only subjective complaint. 

Red raspberries are one of the plant worlds richest sources of vitamins C and K, the essential mineral manganese, and dietary fiber. Contents of vitamin A (from seed carotenoids), B vitamins 1 through 3 (thiamin, riboflavin, niacin, respectively), iron, calcium, and potassium are also at good levels. 

In addition, the essential dietary minerals calcium, iron, potassium, manganese, and magnesium are exceptionally high in content. Phytosterols and omega-3 fat sources (from alpha-linolenic acid) also are pres-... 

Date pulp is low in fat and protein but rich in sugars, mainly fructose and glucose, making it a potent source of caloric energy. It contains excellent amounts of amino acids for protein dietary minerals such as selenium, potassium, calcium, magnesium, manganese, and iron several B vitamins vitamin C omega fatty acids phytosterols and both insoluble and prebi-... 

Copper is recognized as an essential metalloelement like sodium, potassium, magnesium, calcium, iron, zinc, chromium, vanadium and manganese [1]. Like essential amino acids, essential fatty acids and essential cofactors (vitamins), essential metalloelements are required for normal metabolic processes but cannot be synthesized de novo and daily dietary intake and absorption are required. The adult body contains between 1.4 mg (22 pmol) and... 

Information for this table is from Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin Bq, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline (1998) Dietary Reference Intakes for Vitamin C, Vitamin E, Selenium, and Carotenoids (2000) Dietary Reference Intakes for Calcium, Phosphorus, Magnesium, Vitamin D, and Fluoride (1997), Dietary Reference Intakes for Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium, and Zinc (2001). Washington, DC Food and Nutrition Board, Institute of Medicine, National Academy Press. 

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