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Malic derivatives

Alkyl hahdes in the presence of silver oxide react with alkyl malates to yield alkoxy derivatives of succinic acid, eg, 2-ethoxysuccinic acid, H00CCH2CH(0C2H )C00H (12,13). A synthetic approach to produce ethers of malic acid is the reaction of malic esters and sodium alkoxides which affords 2-alkoxysuccinic esters (14). [Pg.521]

Lactic, malic, mandeHc, and oxalic acids also give antimony(III) derivatives ia wliich two molecules of acid are associated with one atom of antimony. Studies of the reaction between antimony trioxide and lactic or oxalic acid as a function of p44 have suggested the foUowiag stmctures for the... [Pg.205]

Coumarin can also be formed by the reaction of phenol with diketene (40). Similarly, diphenols can react with hydroxycarboxyUc acids or beta-ketoesters to give hydroxycoumaria derivatives. The reaction of resorciaol with malic acid produces umbeUiferone (7-hydroxycoumaria) and its reaction with ethyl acetoacetate gives beta-methylumbeUiferone (7-hydroxy-4-methylcoumaria). [Pg.321]

Bromophenol blue (3.0...4.6) aliphatic carboxylic acids [225 — 228] malonic and lactic acids [229] palmitic and lactic acids [230] malonic, glycolic, malic, citric, tartaric, ketoglutaric, galacturonic and oxalic acids [196] dicarboxylic acids, succinic acid [231] indoleacetic acid, trichloroacetic acid [232] palmitic acid, palmityl- and stearyllactic acid [223] benzoic, sorbic and salicylic acid [234] metabolites of ascorbic acid [235] chloropropionic acid [236] oligogalacturonic acids [237] amino acids, hydrocarbons, mono-, di- and triglycerides [238] xylobiose, xylose, glucose and derivatives [239] sugar alcohols [91] toxaphene [240]... [Pg.45]

NADPH can be produced in the pentose phosphate pathway as well as by malic enzyme (Figure 25.1). Reducing equivalents (electrons) derived from glycolysis in the form of NADH can be transformed into NADPH by the combined action of malate dehydrogenase and malic enzyme ... [Pg.805]

Poly(L-malic acid) denotes a family of polyesters derived from L-malic acid as the building unit. By chemical synthesis, three kinds of poly(L-malic acid) have been obtained, depending on the molecular position of the ester bond the a-type(I) [1], the j8-type(II) [2], and the a,j8-mixed-type(III) [3). [Pg.93]

Poly(malic acid) is of pharmaceutical interest because its chemical derivatives may harbor both tissue-specific homing molecules and therapeutic effectors to be used for tissue (tumor) targeting in chemotherapy [2]. Because of its efficient production by fermentation, its biodegradability and nontoxicity, it is also considered as raw material in the industrial production of detergents, glues, and plastic materials. [Pg.93]

Polymalatase may be useful for the tayloring of /3-poly(malic acid) and its derivatives, and for analytical purposes. If the hydrolase is arrested at points of polymer branches or covalently/physically attached ligands, the hydrolase can be used in studies analogous to those known for DNA and exonucleases. [Pg.102]

Thus, enantiomerically pure (S)35- or (R)36-acetoxysuccinimide derivatives of type 1, easily prepared from (S)- or (R)-malic acid, are diastereoselectively reduced with sodium borohydride in methanol at lower temperature to yield 85 % of an 11 1 mixture of diastereomeric hy-droxylactams of type 2, from which the enantiomerically pure chiral /V-acyliminium ions 3 are generated. [Pg.810]

Alpha hydroxy acids (AHAs) are water-soluble substances and thereby penetrate the outermost epidermal skin layers. In contrast, beta hydroxy acids (BHAs) are lipid (fat) soluble and are capable of penetrating to the underlying layers of skin (the dermis) located 1-5 mm below the surface of the skinJ2 Most AHAs are derived from plant materials and marine sources. Commonly used AHAs include malic acid (found in apples), ascorbic acid (a common ingredient in numerous fruits), glycolic acid (a constituent of sugar cane), lactic acid (a component of milk), citric acid (naturally abundant in citrus fruits), and tartatic acid (found in red wine). A common BHA is salicylic acid (an ingredient in aspirin). [Pg.183]

Apparently Fitjer likes to work with p-TsOH in aqueous acetone. Since as of the day of the destruction of the Temple, prophecy has been withdrawn from the prophets and has been given to fools and to babes 43 I shall not prophecy but I shall hazard a prediction. I belive that there are acidic conditions, yet to be found experimentally, which will permit the synthesis of beautiful molecules, by malice aforethought, such as, say, 99, from the properly constituted derivatives of certain rotanes and their homologs. May Fitjer be successful in his quest for [m.njcoronanes but it behooves him, simultaneously, to seek optimal conditions for the preparation of, say, 99 and its propellane homologs. I would even settle for 100 or 101 ... [Pg.20]

Fig. 3 Examples of monomer units having reactive side-chain groups, which can be copolymerized with polyesters (a) a-malic acid, (b) [S-malic acid, (c) a-carboxyl- -caprolactone, (d) carboxy lactic acid, (e) trimethylene carbonate derivative, and (1) depsipeptide... Fig. 3 Examples of monomer units having reactive side-chain groups, which can be copolymerized with polyesters (a) a-malic acid, (b) [S-malic acid, (c) a-carboxyl- -caprolactone, (d) carboxy lactic acid, (e) trimethylene carbonate derivative, and (1) depsipeptide...
The synthesis of 8-homocastanospermine via the 1,3-dipolar cycloaddition of five-membered cyclic nitrone derived from malic acid and unsaturated D-threo-hexaldonolactone is reported <2006CJC534>. [Pg.400]

The 1,3-dipolar cycloaddition of a five-membered cyclic nitrone derived from malic acid and unsaturated D-t/zreu-hexonolactone led to a single adduct 21, which was transformed into 1-homoaustraline via a sequence of well defined reactions (Fig. 7).16 Synthesis of similar derivatives was presented recently.17... [Pg.234]

It has been established that by mixing derivatives of acids having opposite rotation, the compounds had opposite, configurations. The (+) malic acid (XXIV) and (-) mercaptosuccinic acid (XXV) had opposite configurations. [Pg.143]

The cycloaddition of aldehydes and ketones with ketene under the influence of quinine or quinidine produce chiral 2-oxetanones [46,47]. Solvolytic cleavage of the oxetanone, derived from chloral, and further solvolysis of the trichloromethyl group leads to (5)- and (R)-malic acids with a 98% ee [46] (the chirality of the product depends on the configuration of the catalyst at C-8 and, unlike other alkaloid-induced reactions, it is apparently independent of the presence of the hydroxyl group). No attempts have been made to catalyse the reaction with chiral ammonium salts. [Pg.529]

Aside from the multifaceted chemical conversions, there are sources to develop into industrially viable microbial conversions. 1,2,4-Butanetriol, for example, used as an intermediate chemical for alkyd resins and rocket fuels, is currently prepared commercially from malic acid by high-pressure hydrogenation or hydride reduction of its methyl ester. In a novel environmentally benign approach to this chemical, wood-derived D-xylose is microbially oxidized to D-xylonic acid, followed by a multistep conversion to the product effected by a biocatalyst specially engineered by inserting Pseudomonas putida plasmids into E. coli ... [Pg.47]

Cholesterol is required for membrane synthesis, steroid synthesis, and in the liver, bile acid synthesis. Most cells derive their cholesterol from LDL or HDL, but some cholesterol may be synthesized de novo. Most de novo synthesis occurs in the liver, vfhere cholesterol is synthesized from acetyl CoA in the cytoplasm. The citrate shutde carries mitochondrial acetyl CoA into the cytoplasm, and NADPH is provided by the HMP shunt and malic enzyme. Important points are noted in Figure 1-15-9,... [Pg.219]

The name, maleic anhydride, came about in the same fashion. as any number of compounds early in the petrochemical Business Many organic acids and their derivatives were given common names based on some early observations, their special source in nature, or on some special feature of their structure. MA was first isolated in the 1850—75 era by dehydration of malic acid, a sugar acid found in apple juice. The Latin word for apple is malum. Hence, malum, malic, maleic. The suffix, anhydride, which follows each alias of MA, has a simple definition a compound derived by the loss of a molecule of water from two carboxyl groups (-COOH). [Pg.293]

Where we have reason to suspect the involvement of a particular species as a labile intermediate in the course of a reaction, it may be possible to confirm our suspicions by introducing into the reaction mixture, with malice aforethought, a reactive species which we should expect our postulated intermediate to react with particularly readily. It may then be possible to divert the labile intermediate from the main reaction pathway—to trap it—and to isolate a stable species into which it has been unequivocally incorporated. Thus in the hydrolysis of trichloromethane with strong bases cf. p. 46), the highly electron-deficient dichlorocarbene, CClj, which has been suggested as a labile intermediate (p. 267), was trapped by introducing into the reaction mixture the electron-rich species cis but-2-ene (11), and then isolating the resultant stable cyclopropane derivative (12), whose formation can hardly be accounted for in any other way ... [Pg.50]


See other pages where Malic derivatives is mentioned: [Pg.241]    [Pg.20]    [Pg.20]    [Pg.241]    [Pg.20]    [Pg.20]    [Pg.158]    [Pg.424]    [Pg.522]    [Pg.447]    [Pg.287]    [Pg.502]    [Pg.116]    [Pg.146]    [Pg.146]    [Pg.712]    [Pg.123]    [Pg.177]    [Pg.1045]    [Pg.50]    [Pg.692]    [Pg.134]    [Pg.54]    [Pg.102]    [Pg.270]    [Pg.148]    [Pg.1166]    [Pg.421]    [Pg.446]    [Pg.46]   
See also in sourсe #XX -- [ Pg.20 ]




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